Table 2.
Comparison of ventilatory, blood gas and diaphragmatic electrical activity parameters between baseline ventilation, PAV and NAVA
| Baseline | PAV | NAVA | p | Pairwise comparisons | |
|---|---|---|---|---|---|
| “OI” | 11.0 [5.0] | 7.8 [3.2] | 8.1 [3.4] | 0.001 |
n-p 0.70 b-p 0.002 b-n 0.004 |
| Mean airway pressure (cmH2O) | 9.5 [1.1] | 8.3 [1.1] | 9.0 [0.9] | <0.001 |
n-p 0.025 b-p < 0.001 b-n 0.02 |
| FiO2 | 0.40 [0.15] | 0.39 [0.15] | 0.37 [0.13] | <0.001 |
n-p 0.024 b-p 0.28 b-n 0.003 |
| “A-a” gradient (kPa) | 22.9 (11.8) | 20.8 (12.3) | 18.4 (10.8) | <0.001 |
n-p 0.015 b-p 0.127 b-n < 0.001 |
| SpO2/FiO2 | 268 [96] | 268 [92] | 295 [102] | 0.002 |
n-p 0.04 b-p 1.0 b-n 0.04 |
| PO2/FiO2 | 104 (35) | 120 (40) | 126 (42) | 0.001 |
n-p 0.79 b-p 0.033 b-n 0.002 |
| PCO2 [kPa] | 8.1 [1.7] | 8.9 [1.8] | 8.8 [1.7] | 0.026 |
n-p 1.0 b-p 0.007 b-n 0.16 |
| PO2 [kPa] | 5.4 [0.76] | 5.66 [0.68] | 5.6 [1.0] | 0.69 | |
| Respiratory rate (breaths/min) | 61 [9] | 66 [8] | 56 [9] | 0.001 |
n-p 0.003 b-p 0.19 b-n 0.093 |
| Expiratory tidal volume (ml/kg) | 6.2 [0.7] | 6.4 [1.0] | 6.5 [1.2] | 0.32 | |
| Peak inspiratory pressure (cmH2O)* | 17.8 [3.5] | 14.3 [3.0] | b-n < 0.001 | ||
| Positive end-expiratory pressure (cmH2O)* | 5.6 [4.7–7] | 6 [5–7] | b-n 0.94 | ||
| pH | 7.31 [0.67] | 7.29 [0.68] | 7.3 [0.66] | 0.053 | |
| Peak electrical activity of the diaphragm (microvolts) | 13.6 [5.8–40.4] | 13.1 [2.4–38.4] | 11.3 [5.2–28.5] | 0.33 | |
| Minimum electrical activity of the diaphragm (microvolts) | 2.2 [0.9–4.2] | 2.3 [0.7–4.2] | 2.4 [0.7–4.5] | 0.92 |
Results are presented as mean (standard deviation) or median [range]
n-p = comparison between NAVA and PAV; b-p = comparison between baseline and PAV
b-n = comparison between baseline and NAVA
*Data unavailable for two infants