Table 3.
Adverse events occurred in ≥10% of patients overall.
| Events | Grade (n) | Total incidence (%) | Grade 3 incidence (%) | ||
|---|---|---|---|---|---|
| 1 | 2 | 3 | |||
| Diarrhea | 11 | 9 | 0 | 47.6 | 0 |
| Hypertension | 14 | 3 | 2 | 45.2 | 4.8 |
| Hand-foot skin reaction | 8 | 9 | 1 | 42.9 | 2.4 |
| Fatigue | 12 | 4 | 1 | 40.5 | 2.4 |
| Proteinuria | 9 | 6 | 0 | 35.7 | 0 |
| Anorexia | 10 | 3 | 1 | 33.3 | 2.4 |
| Hypothyroidism | 6 | 4 | 2 | 28.6 | 4.8 |
| Hoarseness | 10 | 1 | 0 | 26.2 | 0 |
| Rash | 4 | 6 | 0 | 23.8 | 0 |
| Hypertriglyceridemia | 5 | 3 | 1 | 21.4 | 2.4 |
| Hypercholesterolemia | 7 | 2 | 0 | 21.4 | 0 |
| Oral mucositis | 4 | 5 | 0 | 21.4 | 0 |
| Elevated GGT | 5 | 0 | 3 | 19.0 | 7.1 |
| Hyponatremia | 3 | 4 | 1 | 19.0 | 2.4 |
| Pharyngalgia | 5 | 2 | 1 | 19.0 | 2.4 |
| Low back and leg pain | 6 | 0 | 0 | 14.3 | 0 |
| Elevated TSH | 4 | 1 | 0 | 11.9 | 0 |
| Constipation | 5 | 0 | 0 | 11.9 | 0 |
| Abdominal pain | 2 | 2 | 1 | 11.9 | 2.4 |
| Cough | 2 | 3 | 0 | 11.9 | 0 |
| Vomit | 4 | 1 | 0 | 11.9 | 0 |
GGT, γ-Glutamyl transpeptidase; TSH, Thyroid-stimulating hormone.