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. 2020 May 7;11:434. doi: 10.3389/fphys.2020.00434

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Copyright © 2020 Toprak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram summarizing the interaction between the insulin signaling and the transcription factor cAMP response element-binding protein. Abbreviations: Ca, calcium; CREB, cAMP response element-binding protein; PO₄, phosphate; SIK2, salt induced kinase 2; CRTC, cAMP-regulated transcriptional co-activator.