| PARP inhibitors are a family of enzymes that play a role in DNA repair. |
| Tumors carrying mutations in BRCA1/2 and other genes implicated in homologous repair deficiency are particularly sensitive to PARP inhibition. |
| Talazoparib has greater stereospecific PARP-DNA trapping ability than other PARP inhibitors. |
| Evidence supporting the use of talazoparib in the treatment of ovarian cancer is limited in comparison with other PARP inhibitors. |
| Talazoparib has mostly been investigated in breast cancer. |
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