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. 2020 Apr 30;14(5):745–754. doi: 10.1016/j.stemcr.2020.03.027

Figure 1.

Figure 1

Transition of Early to Late Naive State is Associated with Increased XIST Expression and Reduction in X-Linked Gene Expression

(A) Schematic representation of different stages and corresponding X chromosome states of conversion of primed hPSCs to naive state as described in Sahakyan et al., 2017a. In this study, we performed analysis of the scRNA-seq dataset acquired from the early and late naive state.

(B) Comparison of XIST expression (RPKM) between early naive (n = 28) cells and late naive (n = 30) cells. p < 0.00001 (Mann-Whitney U test).

(C) Comparison of X-linked gene expression (n = 57 genes) between early naïve (n = 28) cells and late naive (n = 30) cells. p < 0.00001 (Mann-Whitney U test).