Table 3.
Description of the matched sample
| Admission category | Other categories | Sepsis | p value |
|---|---|---|---|
| N | 824 | 443 | |
| Age (years)a | 82 (81–85) | 83 (81–85) | 0.5618 |
| Gender (male) | 435 (52.8%) | 233 (52.6%) | 0.9941 |
| Hospital LOS before ICU admission (days)a | 1 (0–3) | 1 (0–3) | 0.28 |
| SOFA score at admissiona | 8 (6–11) | 8 (6–12) | 0.5468 |
| ICU LOS (days)a | 3.29 (1.33–7.85) | 3.88 (1.67–8.53) | 0.2454 |
| Frailty (CFS) | 0.6963 | ||
| Fit (CFS 1–3) | 273 (33.1%) | 144 (32.5%) | |
| Vulnerable (CFS 4) | 105 (12.7%) | 64 (14.4%) | |
| Frail (CFS 5–9) | 446 (54.1%) | 235 (53%) | |
| Therapeutic interventions in ICU | |||
| At least one | 723 (87.7%) | 389 (87.8%) | 0.999 |
| Mechanical ventilation | 480 (58.3%) | 202 (45.6%) | < 0.0001 |
| Non-invasive ventilation | 239 (29%) | 100 (22.6%) | 0.0164 |
| Vasoactive drugs | 500 (60,7%) | 361 (81.5%) | < 0.0001 |
| RRT | 115 (14%) | 77 (17.4%) | 0.1238 |
| Life-sustaining treatment limitations | |||
| No LST limitations | 568 (68.9%) | 286 (64.6%) | 0.1284 |
| LST limitations | 256 (31.1%) | 157 (35.4%) | |
| Withholding | 128 (15.5%) | 98 (22.1%) | 0.0124 |
| Withdrawing ± withholding | 128 (15.5%) | 59 (13.3%) | |
| ICU mortality | 239 (29%) | 126 (28.4%) | 0.8841 |
| 30-day mortality | 337 (40.9%) | 187 (42.2%) | 0.6942 |
443 patients with sepsis were matched to 824 patients without sepsis
62 patients had only one match and 55 could not be matched
Survival was similar; sepsis HR 1.02 (95% CI 0.85–1.22), p = 0.854
LOS length of stay, SOFA Sequential Organ Failure Assessment, CFS Clinical Frailty Score, RRT renal replacement therapy, LST life-sustaining treatment
aExpressed in median, IQR