FIGURE 6.

Alterations in lipid mediators of inflammation resolution (LMIR) in the lungs of healthy and MetS mice following AgNP exposure and the effect of statins. Exploratory lipid profiling suggests variations in lipids involved in the synthesis of (A) eicosapentaenoic acid (EPA) and docosapentaenoic acid (DHA). * denotes lipids significantly reduced only in MetS in response to AgNP exposure, while $ denotes lipids significantly reduced in AgNP exposed MetS compared to AgNP exposed healthy mice (p < 0.05). (B) Representative lipids within the EPA and DHA pathway altered due to AgNP in healthy and MetS mice. * denotes lipids significantly reduced only in MetS in response to AgNP exposure, while $ denotes lipids significantly reduced in exposed MetS compared to exposed healthy mice, and # denotes significant differences due to statin treatment (p < 0.05). Graphs of other components of the pathway can be found in Supplementary Figure S2.