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. 2020 May 7;11:733. doi: 10.3389/fmicb.2020.00733

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Copyright © 2020 Banerjee, Kulkarni and Mukherjee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Herpes simplex virus (HSV) entry and release at the cell membrane. (A) Attachment. The HSV envelope glycoproteins gB, gD, and gH/gL interact with the receptors on the cell membrane. (B) Penetration. Entry of HSV into the cell takes place either by membrane fusion, where the membrane of the virus and the cell fuse for the cellular uptake of the nucleocapsid only or, by endocytosis, where the enveloped virus is engulfed in an endosome followed by endosome fusion to release the nucleocapsids. The nucleocapsids enter into the nucleus for viral replication. (C) Release. The HSV progenies are released into the cytoplasm, acquire the membrane from the host cell in a process called budding.