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. 2020 May 7;12:116. doi: 10.3389/fnagi.2020.00116

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Copyright © 2020 González-Roldán, Terrasa, Sitges, van der Meulen, Anton and Montoya.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional connectivity differences between pain-related regions of interest (ROIs) in the older group as compared to the younger group. (A) Increased connectivity in the older group. (B) Decreased connectivity in the older group. SI, primary somatosensory cortex; SII, secondary somatosensory cortex; ACC, anterior cingulate cortex; dlPFC, dorsolateral prefrontal cortex; INS, insula; AMY, amygdala; PAG, periaqueductal gray matter; THA, thalamus.