FIGURE 2.

Alignment of nAChR α7 subunit protein sequences of the cockroach P. americana with its orthologs in several insect species and human. The loops (LpA-F) involved in ligand binding and transmembrane motifs (TM1-4) forming the ion channel are indicated. Sites of cysteine residues involved in the Cys-loop are marked with asterisk; the vicinal cysteine residues characteristic of alpha-type and the key residues are shown in frame. Alignment was done with drosophila sequence as reference, identical residues (dark gray shading) and similar residues (light gray shading) are indicated.