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. 2020 May 7;11:418. doi: 10.3389/fphys.2020.00418

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Copyright © 2020 Cartereau, Taillebois, Selvam, Martin, Graton, Le Questel and Thany.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of nicotine (Nic) and acetylcholine (ACh) on cockroach α7 nAChRs expressed in Xenopus laevis oocytes. (A) Typical example of nicotine- and acetylcholine-induced currents. Currents are recorded at 10 mM nicotine or acetylcholine, respectively. (B) Dose-response curve are represented for nicotine and acetylcholine. Data are normalized to 10 mM nicotine and each point represents a mean ± S.E.M of n = 12 tested oocytes. (C,D) Nicotine (10 mM) evoked currents recorded after the expression of cockroach α7 subunit alone or with rat RIC-3. Each histogram represents mean ± S.E.M of n = 10 oocytes. NS = no significant difference using one-way ANOVA and Bonferroni post hoc test.