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Effect of nAChR antagonists on nicotine evoked currents. (A) 5 min pretreatment with 10 μM α-Bgt, (B) 10 μM MLA, (C) 5 μM mecamylamine (MEC), and (D) 10 μM d-TC. Bars indicate application of 10 s nicotine at 10 mM. Histograms illustrate the effect of each antagonist on nicotine-evoked currents. In each case, data are mean ± S.E.M of n = 12 oocytes, *p < 0.05 using one-way ANOVA and Bonferroni post hoc test. NS = no significant.
