Table 3.
Radiomic features that show concordance and non-redundancy in the test–retest cohort (CCC and DR ≥ 0.65;Rsq ≥ 0.99) for (A) radiologist-marked region, (B) habitat region (sphere, 15 mm), (C) habitat (≤ median, ADC).
| (A). Radiologist regions | |
|---|---|
| Radiologist marked region (T2): CCC and DR > = 0.65; Rsq ≥ 0.99. | |
| T2 (raw): 19 features | T2 (z-normalized): 12 features |
| F138:GLSZM_Large-zone-low-gray-level-emphasis- F149:NGTDM_Contrast- F10:Stat-Max-gray-level F150:NGTDM_Busyness- F107:avgCooc_3D_Inv-diff-mom-norm F284:3D-Wave-P1-L2-C4- F115:avgCooc_3D_Second-measure-of-information-correlation- F113:avgCooc_3D_Cluster-prominence-F93:avgCooc_3D_Joint-var F99:avgCooc_3D_Sum-var-F151:NGTDM_Complexity F302:3D-Wave-P1-L2-C13 F300:3D-Wave-P1-L2-C12 F27:Int-hist-90th-percentile F294:3D-Wave-P1-L2-C9 F304:3D-Wave-P1-L2-C14 F152:NGTDM_Strength |
F19:Stat-Root-Mn-Sq- F149:NGTDM_Contrast- F10:Stat-Max-gray-level- F12:Stat-range- F107:avgCooc_3D_Inv-diff-mom-norm- F171:3D-LawsF-L5-R5-R5- F284:3D-Wave-P1-L2-C4- F3:Stat-SD- F152:NGTDM_Strength- F8:Stat-10th-percentile- |
| Shape and Size | Shape and size |
| F47:Vol-at-Int-fraction-diff F43:Vol-at-Int-Fraction-10- | F47:Vol-at-Int-fraction-diff- F43:Vol-at-Int-Fraction-10- |
| Radiologist marked region (ADC): CCC and DR ≥ 0.65; Rsq ≥ 0.99 | |
| ADC (raw): two features | ADC (z-normalized): three features |
| F9:Stat-90th percentile F8:Stat-10th percentile |
F96:avgCooc_3D_Difference-var F120:avg_3D_SRLGE-(Short-run-low-gray-level-emphasis) Shape and size F88:Center-of-mass-shift-(mm) |
| (B). Habitat regions | |
| Habitat using sphere (ADC): CCC and DR ≥ 0.65; Rsq ≥ 0.99 | |
| ADC (raw): 15 features | ADC (z-score): 15 features |
| F228:3D-LawsF-R5-L5-L5-ADC-Auto F126:avg_3D_RLN-(Run-length-non-uniformity)-ADC F157:3D-LawsF-L5-L5-W5-ADC F231:3D-LawsF-R5-L5-R5-ADC F246:3D-LawsF-R5-R5-R5-ADC F170:3D-LawsF-L5-R5-S5-ADC F154:3D-LawsF-L5-L5-E5-ADC F155:3D-LawsF-L5-L5-S5-ADC F169:3D-LawsF-L5-R5-E5-ADC F171:3D-LawsF-L5-R5-R5-ADC F140:GLSZM_Gray-level-non-uniformity F124:avg_3D_GLN-(Gray-level-non-uniformity) F148:NGTDM_Coarseness |
F302:3D-Wave-P1-L2-C13-ADC F294:3D-Wave-P1-L2-C9-ADC F218:3D-LawsF-S5-R5-L5-ADC F296:3D-Wave-P1-L2-C10-ADC F304:3D-Wave-P1-L2-C14-ADC F228:3D-LawsF-R5-L5-L5-ADC F243:3D-LawsF-R5-R5-L5-ADC F198:3D-LawsF-E5-W5-L5-ADC F151:NGTDM_Complexity-ADC F140:GLSZM_Gray-level-non-uniformity-ADC F7:Stat-Min-gray-level-ADC F115:avgCooc_3D_Second-measure-of-information-correlation-ADC F148:NGTDM_Coarseness-ADC |
| Shape and size: | Shape and size: |
| F90:Border-length-(mm) F54:Surface-area-(mm∧2)-ADC |
F52:Vol-(mm∧3)-ADC F54:Surface-area-(mm∧2)-ADC |
| Habitats using sphere (T2): CCC and DR > = 0.65; Rsq ≥0.99 | |
| T2 (raw): 18 features | T2 (z-normalized): 23 features |
| F117:avg_3D_LRE-(Long-runs-emphasis)-ADC F126:avg_3D_RLN-(Run-length-non-uniformity)-ADC F144:GLSZM_Zone-percentage-ADC F27:Int-hist-90th-percentile-ADC F100:avgCooc_3D_Sum-entropy-ADC F161:3D-LawsF-L5-E5-R5-ADC F141:GLSZM_Gray-level-non-uniformity-normalized-ADC- F124:avg_3D_GLN-(Gray-level-non-uniformity)-ADC F150:NGTDM_Busyness-ADC F243:3D-LawsF-R5-R5-L5-ADC F149:NGTDM_Contrast-ADC F231:3D-LawsF-R5-L5-R5-ADC F300:3D-Wave-P1-L2-C12-ADC F140:GLSZM_Gray-level-non-uniformity-ADC F115:avgCooc_3D_Second-measure-of-information-correlation-ADC F114:avgCooc_3D_First-measure-of-information-correlation-ADC F148:NGTDM_Coarseness-ADC |
F115:avgCooc_3D_Second-measure-of-information-correlation-ADC F149:NGTDM_Contrast-ADC F29:Int-hist-mode-ADC F19:Stat-Root-Mn-Sq-ADC F159:3D-LawsF-L5-E5-E5-ADC F122:avg_3D_LRLGE-(Long-run-low-gray-level-emphasis)-ADC F298:3D-Wave-P1-L2-C11-ADC F306:3D-Wave-P1-L2-C15-ADC F40:Max-hist-Gradient-gray-level-ADC F42:Min-hist-Gradient-gray-level-ADC F8:Stat-10th-percentile-ADC F136:GLSZM_Small-zone-low-gray-level-emphasis-ADC F152:NGTDM_Strength-ADC F139:GLSZM_Large-zone-high-gray-level-emphasis-ADC F97:avgCooc_3D_Difference-entropy-ADC- F41:Min-hist-Gradient-ADC- F140:GLSZM_Gray-level-non-uniformity-ADC F231:3D-LawsF-R5-L5-R5-ADC F54:Surface-area-(mm∧2)-ADC F114:avgCooc_3D_First-measure-of-information-correlation-ADC F148:NGTDM_Coarseness-ADC |
| Shape and Size: | Shape and Size: |
| F54:Surface-area-(mm∧2)- | F88:Center-of-mass-shift-(mm)-ADC F87:Weighted-CoM_z-(mm)-ADC |
| (C). Habitat within lesion | |
| Habitat within lesion (≤ Median): ADC: CCC and DR ≥ 0.65; Rsq ≥ 0.99 | |
| ADC (raw): 1 feature | ADC (z-normalized): 1 feature |
| F10:Stat-Max-gray-level-ADC | F143:GLSZM_Zone-size-non-uniformity-normalized-ADCz-Auto |
| Habitat within lesion (≤ Median): T2: CCC and DR ≥ 0.65; Rsq ≥0.99 | |
| T2 (raw): 12 features | T2 (z-normalized): 10 features |
| F93:avgCooc_3D_Joint-var-ADC-T2 F151:NGTDM_Complexity-ADC-T2 F152:NGTDM_Strength-ADC-T2 F27:Int-hist-90th-percentile-ADC-T2 F131:avg_3D_RE-(Run-entropy)-ADC-T2 F113:avgCooc_3D_Cluster-prominence-ADC-T2 F282:3D-Wave-P1-L2-C3-ADC-T2 F290:3D-Wave-P1-L2-C7-ADC-T2 F149:NGTDM_Contrast-ADC-T2 F18:Stat-ENERGY-ADC-T2 F40:Max-hist-Gradient-gray -level-ADC-T2 F99:avgCooc_3D_Sum-var-ADC-T2 |
F3:Stat-SD-T2z F9:Stat-90th-percentile-T2z F149:NGTDM_Contrast-T2z F93:avgCooc_3D_Joint-var-T2z F27:Int-hist-90th-percentile-T2z F113:avgCooc_3D_Cluster-prominence-T2z F151:NGTDM_Complexity-T2z F152:NGTDM_Strength-T2z F19:Stat-Root-Mn-Sq-T2z F30:Int-hist-interquartile-range-T2z |