TABLE 1.
Protein expression level (pmol per mg protein) in brain microvessels and choroid plexus.
|
Brain microvessel |
Choroid plexus |
|||||
| Gene | Alias | Human | Mouse | Rat | Dog | Dog |
| ABC transporters | ||||||
| ABCB1 | P-gp | 6.1 | 17.8 | 19.1 | 6.2 | 0.14 |
| ABCG2 | BCRP | 8.1 | 5.5 | 5.0 | <LOQ | |
| SLC transporters | ||||||
| SLC2A1 | GLUT1 | 139 | 101 | 91 | 194 | 57 |
| SLC7A5 | LAT1 | 0.43 | 1.2 | 3.0 | <LOQ | <LOQ |
| SLC3A2 | 4F2hc | 3.5 | 23.3 | 5.8 | ||
| SLC7A1 | CAT1 | 1.1 | ||||
| SLC16A1 | MCT1 | 2.3 | 13.7 | 12.6 | <LOQ | 1.5 |
| SLC1A3 | EAAT1 | 25 | ||||
| Receptors | ||||||
| INSR | IR | 1.1 | 1.1 | 1.0 | <LOQ | 0.57 |
| TFRC | TfR1 | 2.3 | 5.2 | 7.8 | 16.2 | 9.1 |
| Structural proteins/enzymes | ||||||
| CLDN5 | Claudin-5 | 3.6 | 8.1 | 7.5 | ||
| GGT1 | gGTP | 2.1 | 3.2 | 3.3 | ||
| Non-endothelial cell proteinsa | ||||||
| GFAP | GFAP | 503 | ||||
| CSPG4 | NG2 | 1.1 | ||||
| CNP | CNPase | 13 | ||||
| SYP | p38 | 1.5 | ||||
From Shawahna et al. (2011), Uchida et al. (2011, 2013), Hoshi et al. (2013), and Braun et al. (2017); LOQ, limit of quantitation. aGFAP, glial fibrillary acidic protein is an astrocyte marker; CSPG4, chondroitin sulfate proteoglycan 4, also known as NG2 proteoglycann is a pericyte marker; CNP, 2’,3’-cyclic nucleotide 3’-phosphodiesterase is an oligodendrocyte marker; SYP, synaptophysin is a nerve ending marker.