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Estimation of the number of participants per group required for the significant detection of “Time × Group” coefficients (type-I error rates: 0.05 and 5.576 · 10−4; minimum detection power: 80%) for each metabolite according to the coefficient values obtained in these study models. In the upper right corner, there is a resized section of the overall curves clarifying the metabolites for which the estimated number of participants per group is ≤150.
