Table 1.
Descriptive statistics from the pre-processed data, with main results from the models evaluated for each metabolite.
| Metabolite Name | Baseline | Post session 1 | Post session 5 | Coefficient for “Time” ** |
Coefficient for “Group” ** ^ |
Coefficient for “Time × Group” ** |
|||
|---|---|---|---|---|---|---|---|---|---|
| tDCS Group * | Sham Group * | tDCS Group * | Sham Group * | tDCS Group * | Sham Group * | ||||
| 2-Aminoadipic acid | 39; 0.012 (0.166) | 39; −0.012 (0.156) | 40; 0.092 (0.153) | 39; 0.062 (0.177) | 39; 0.228 (0.136) | 39; −0.106 (0.151) | −0.018 (0.027); 0.434; 0.51 | 0.001 (0.193); 0; 0.994 | 0.073 (0.041); 3.113; 0.078 |
| 2-Aminoisobutyric acid | 40; 0.127 (0.129) | 39; −0.13 (0.185) | 40; 0.137 (0.131) | 39; −0.065 (0.18) | 40; 0.283 (0.141) | 39; 0.217 (0.156) | 0.092 (0.726); 0.016; 0.899 | 0.629 (3.6); 0.031; 0.861 | −0.172 (1.137); 0.023; 0.88 |
| 3-Hydroxyanthranilic acid | 40; 0.055 (0.151) | 39; −0.056 (0.169) | 40; −0.051 (0.128) | 39; −0.139 (0.168) | 40; −0.082 (0.153) | 39; −0.092 (0.143) | −0.011 (0.025); 0.206; 0.65 | 0.082 (0.206); 0.158; 0.691 | −0.012 (0.036); 0.11; 0.74 |
| 4-Pyridoxic acid | 40; −0.044 (0.121) | 39; 0.045 (0.192) | 40; -0.067 (0.118) | 39; 0.034 (0.186) | 40; −0.05 (0.16) | 39; 0.214 (0.19) | 0.037 (0.019); 3.726; 0.054 | −0.091 (0.229); 0.158; 0.691 | −0.03 (0.029); 1.032; 0.31 |
| Acetoacetic acid | 40; 0.005 (0.154) | 39; −0.005 (0.167) | 40; −0.044 (0.158) | 39; −0.193 (0.174) | 40; −0.223 (0.18) | 39; −0.148 (0.163) | −0.012 (0.018); 0.413; 0.52 | 0.075 (0.228); 0.107; 0.744 | −0.031 (0.028); 1.207; 0.272 |
| Adenine | 40; −0.021 (0.176) | 39; 0.022 (0.142) | 40; −0.174 (0.132) | 39; 0.007 (0.195) | 40; 0.04 (0.135) | 39; −0.044 (0.134) | −0.012 (0.027); 0.205; 0.651 | −0.103 (0.223); 0.215; 0.643 | 0.029 (0.042); 0.46; 0.498 |
| Adenosine | 40; −0.066 (0.164) | 39; 0.067 (0.155) | 40; 0.252 (0.163) | 39; 0.225 (0.177) | 40; 0.057 (0.186) | 39; 0.378 (0.167) | 0.054 (0.024); 4.931; 0.026 | −0.03 (0.223); 0.018; 0.893 | −0.061 (0.044); 1.963; 0.161 |
| Adenosine monophosphate | 40; 0.04 (0.142) | 39; −0.041 (0.177) | 40; 0.101 (0.138) | 39; 0.349 (0.145) | 40; 0.251 (0.123) | 39; 0.211 (0.14) | 0.044 (0.027); 2.721; 0.099 | −0.082 (0.205); 0.161; 0.688 | 0.005 (0.038); 0.017; 0.895 |
| Allantoin | 40; 0.038 (0.173) | 39; −0.039 (0.144) | 40; −0.125 (0.174) | 39; −0.103 (0.154) | 40; −0.312 (0.177) | 39; −0.177 (0.154) | −0.017 (0.025); 0.439; 0.507 | 0.067 (0.228); 0.086; 0.769 | −0.049 (0.042); 1.348; 0.246 |
| alpha-D-glucuronic acid | 40; −0.016 (0.165) | 39; 0.016 (0.155) | 40; −0.176 (0.158) | 39; −0.071 (0.172) | 40; −0.054 (0.15) | 39; −0.132 (0.142) | -0.028 (0.021); 1.87; 0.172 | −0.073 (0.226); 0.103; 0.748 | 0.032 (0.034); 0.879; 0.348 |
| Asymmetric dimethylarginine | 40; −0.145 (0.16) | 39; 0.149 (0.157) | 40; 0.171 (0.135) | 39; 0.062 (0.134) | 40; 0.034 (0.132) | 39; 0.236 (0.154) | 0.022 (0.041); 0.282; 0.595 | −0.13 (0.176); 0.547; 0.459 | 0.012 (0.051); 0.055; 0.815 |
| Betaine | 40; 0.008 (0.16) | 39; −0.008 (0.16) | 40; −0.083 (0.153) | 39; 0.048 (0.133) | 40; 0.01 (0.176) | 39; 0.003 (0.119) | 0.005 (0.027); 0.036; 0.85 | −0.04 (0.212); 0.036; 0.849 | 0.003 (0.044); 0.004; 0.95 |
| Carnosine | 40; 0.114 (0.153) | 39; −0.116 (0.165) | 40; 0.05 (0.143) | 39; 0.061 (0.134) | 40; 0.064 (0.129) | 39; −0.004 (0.115) | 0.021 (0.025); 0.752; 0.386 | 0.177 (0.217); 0.662; 0.416 | −0.028 (0.033); 0.711; 0.399 |
| Chenodeoxycholic acid | 40; 0.046 (0.143) | 39; −0.047 (0.176) | 40; 0.026 (0.138) | 39; −0.14 (0.167) | 40; −0.286 (0.123) | 39; −0.133 (0.186) | −0.013 (0.023); 0.321; 0.571 | 0.159 (0.224); 0.501; 0.479 | −0.061 (0.034); 3.145; 0.076 |
| Cholic acid | 30; 0.08 (0.186) | 28; −0.086 (0.188) | 26; −0.159 (0.209) | 25; −0.175 (0.161) | 27; 0.002 (0.194) | 23; −0.387 (0.202) | −0.018 (0.047); 0.151; 0.697 | 0.252 (0.27); 0.867; 0.352 | −0.004 (0.072); 0.003; 0.955 |
| Choline | 40; 0.03 (0.148) | 39; −0.031 (0.171) | 40; −0.024 (0.175) | 39; −0.044 (0.157) | 40; −0.121 (0.158) | 39; 0.05 (0.197) | 0.019 (0.036); 0.287; 0.592 | 0.006 (0.223); 0.001; 0.979 | −0.038 (0.05); 0.578; 0.447 |
| Citrulline | 40; 0.035 (0.166) | 39; −0.036 (0.154) | 40; −0.127 (0.152) | 39; −0.163 (0.151) | 40; −0.229 (0.182) | 39; −0.164 (0.18) | −0.014 (0.026); 0.284; 0.594 | 0.081 (0.217); 0.138; 0.71 | −0.036 (0.034); 1.085; 0.298 |
| Creatine | 40; 0.302 (0.151) | 39; −0.309 (0.154) | 40; 0.308 (0.146) | 39; −0.074 (0.133) | 40; 0.229 (0.141) | 39; −0.051 (0.137) | 0.057 (0.019); 8.719; 0.003 | 0.516 (0.21); 6.014; 0.014 | −0.072 (0.028); 6.578; 0.01 |
| Creatinine | 40; −0.087 (0.154) | 39; 0.089 (0.165) | 40; −0.098 (0.149) | 39; −0.024 (0.157) | 40; −0.026 (0.164) | 39; 0.076 (0.176) | 0.005 (0.015); 0.098; 0.754 | −0.118 (0.218); 0.293; 0.588 | 0.008 (0.022); 0.129; 0.72 |
| Cyclic AMP | 40; 0.129 (0.174) | 39; −0.133 (0.141) | 40; 0.086 (0.141) | 39; −0.054 (0.14) | 40; 0.043 (0.135) | 39; 0.021 (0.141) | 0.02 (0.023); 0.77; 0.38 | 0.184 (0.188); 0.956; 0.328 | −0.044 (0.045); 0.967; 0.326 |
| Cytidine | 40; 0.038 (0.14) | 39; −0.039 (0.179) | 40; −0.013 (0.133) | 39; −0.054 (0.177) | 40; −0.045 (0.167) | 39; 0.066 (0.195) | 0.016 (0.035); 0.207; 0.649 | 0.089 (0.228); 0.153; 0.696 | −0.04 (0.046); 0.762; 0.383 |
| Cytosine | 40; −0.013 (0.18) | 39; 0.013 (0.137) | 40; −0.079 (0.16) | 39; 0.015 (0.139) | 40; −0.304 (0.16) | 39; −0.232 (0.14) | −0.04 (0.026); 2.348; 0.125 | −0.033 (0.232); 0.021; 0.886 | −0.012 (0.042); 0.084; 0.772 |
| D-Ribose-5-phosphate | 40; 0.053 (0.162) | 39; −0.054 (0.157) | 40; 0.038 (0.147) | 39; 0.02 (0.144) | 40; 0.129 (0.128) | 39; −0.023 (0.14) | 0.02 (0.027); 0.555; 0.456 | 0.09 (0.22); 0.17; 0.68 | −0.002 (0.042); 0.002; 0.969 |
| Decanoylcarnitine | 40; 0.04 (0.156) | 39; −0.041 (0.165) | 40; −0.105 (0.18) | 39; −0.401 (0.18) | 40; −0.36 (0.173) | 39; −0.287 (0.112) | 0.005 (0.039); 0.015; 0.902 | 0.061 (0.226); 0.072; 0.788 | −0.069 (0.051); 1.878; 0.171 |
| Deoxycytidine | 40; 0.018 (0.128) | 39; −0.018 (0.188) | 40; −0.036 (0.123) | 39; −0.127 (0.184) | 40; −0.267 (0.136) | 39; −0.044 (0.177) | −0.01 (0.014); 0.528; 0.468 | 0.057 (0.227); 0.064; 0.8 | −0.051 (0.025); 4.151; 0.042 |
| Deoxyuridine | 40; −0.02 (0.151) | 39; 0.02 (0.169) | 40; 0.058 (0.153) | 39; −0.025 (0.17) | 40; 0.031 (0.139) | 39; 0.121 (0.189) | 0.026 (0.02); 1.6; 0.206 | −0.026 (0.225); 0.013; 0.908 | −0.018 (0.029); 0.372; 0.542 |
| Dimethylglycine | 40; −0.106 (0.145) | 39; 0.109 (0.173) | 40; −0.129 (0.145) | 39; -0.007 (0.162) | 40; −0.089 (0.13) | 39; 0.112 (0.169) | −0.061 (0.031); 3.848; 0.05 | −0.311 (0.24); 1.673; 0.196 | 0.053 (0.037); 2.086; 0.149 |
| Folic acid | 40; 0.063 (0.175) | 39; −0.064 (0.142) | 40; 0.181 (0.16) | 39; 0.016 (0.134) | 40; −0.053 (0.184) | 39; −0.169 (0.148) | −0.034 (0.026); 1.706; 0.191 | 0.083 (0.21); 0.156; 0.693 | −0.006 (0.037); 0.025; 0.875 |
| Gamma-Aminobutyric acid | 40; −0.116 (0.163) | 39; 0.119 (0.155) | 40; 0.004 (0.155) | 39; −0.102 (0.149) | 40; 0.184 (0.148) | 39; −0.18 (0.129) | −0.05 (0.032); 2.479; 0.115 | −0.112 (0.183); 0.372; 0.542 | 0.105 (0.051); 4.207; 0.04 |
| Gamma-Glutamylcysteine | 38; −0.05 (0.169) | 34; 0.055 (0.165) | 37; −0.205 (0.133) | 38; 0.035 (0.175) | 38; 0.014 (0.159) | 34; −0.005 (0.145) | −0.014 (0.019); 0.505; 0.477 | −0.188 (0.218); 0.743; 0.389 | 0.042 (0.029); 2.127; 0.145 |
| Glyceraldehyde | 40; 0.167 (0.143) | 39; −0.171 (0.172) | 40; −0.089 (0.135) | 39; −0.271 (0.163) | 40; 0.089 (0.139) | 39; −0.243 (0.154) | −0.007 (0.029); 0.064; 0.8 | 0.298 (0.209); 2.026; 0.155 | 0.001 (0.045); 0; 0.991 |
| Glycine | 40; −0.296 (0.169) | 39; 0.304 (0.133) | 40; −0.319 (0.177) | 39; 0.36 (0.143) | 40; −0.304 (0.183) | 39; 0.094 (0.125) | −0.039 (0.018); 4.72; 0.03 | −0.685 (0.216); 10.095; 0.001 | 0.033 (0.029); 1.291; 0.256 |
| Glycocholic acid | 40; 0.011 (0.165) | 39; −0.012 (0.155) | 40; −0.31 (0.172) | 39; −0.465 (0.164) | 40; −0.61 (0.163) | 39; −0.467 (0.153) | −0.092 (0.036); 6.521; 0.011 | 0.067 (0.233); 0.082; 0.775 | −0.039 (0.048); 0.681; 0.409 |
| Guanidoacetic acid | 40; 0.028 (0.149) | 39; −0.029 (0.171) | 40; −0.159 (0.144) | 39; −0.209 (0.169) | 40; 0.005 (0.2) | 39; −0.216 (0.187) | −0.021 (0.023); 0.838; 0.36 | 0.071 (0.223); 0.102; 0.749 | 0.025 (0.037); 0.439; 0.508 |
| Guanosine | 40; −0.068 (0.159) | 39; 0.07 (0.16) | 40; 0.179 (0.133) | 39; 0.023 (0.161) | 40; −0.064 (0.137) | 39; 0.06 (0.161) | 0 (0.022); 0; 0.994 | −0.014 (0.198); 0.005; 0.943 | −0.026 (0.031); 0.681; 0.409 |
| Hexanoylcarnitine | 40; 0.133 (0.162) | 39; −0.136 (0.155) | 40; −0.165 (0.161) | 39; −0.496 (0.165) | 40; −0.251 (0.177) | 39; −0.45 (0.127) | −0.067 (0.031); 4.866; 0.027 | 0.253 (0.227); 1.235; 0.266 | −0.002 (0.044); 0.002; 0.961 |
| Hippuric acid | 40; −0.254 (0.145) | 39; 0.261 (0.164) | 40; −0.451 (0.135) | 39; 0.039 (0.159) | 40; 0.003 (0.192) | 39; 0.116 (0.167) | −0.029 (0.034); 0.718; 0.397 | −0.515 (0.224); 5.288; 0.021 | 0.083 (0.045); 3.437; 0.064 |
| Homocysteine | 40; -0.08 (0.15) | 39; 0.082 (0.169) | 40; −0.094 (0.156) | 39; 0.088 (0.168) | 40; −0.118 (0.146) | 39; 0.125 (0.158) | 0.017 (0.035); 0.235; 0.628 | −0.171 (0.25); 0.468; 0.494 | −0.029 (0.047); 0.387; 0.534 |
| Homogentisic acid | 40; 0.144 (0.165) | 39; −0.147 (0.151) | 40; −0.06 (0.135) | 38; −0.261 (0.183) | 40; −0.131 (0.131) | 39; −0.102 (0.137) | 0.02 (0.022); 0.865; 0.352 | 0.281 (0.215); 1.705; 0.192 | −0.066 (0.034); 3.668; 0.055 |
| Hydroxykynurenine | 40; 0.053 (0.158) | 39; −0.055 (0.161) | 40; −0.004 (0.128) | 39; −0.043 (0.171) | 40; −0.092 (0.154) | 39; 0.143 (0.156) | 0.038 (0.025); 2.291; 0.13 | 0.058 (0.213); 0.074; 0.785 | −0.069 (0.037); 3.59; 0.058 |
| Hypoxanthine | 40; 0.135 (0.155) | 39; −0.138 (0.163) | 40; −0.129 (0.117) | 39; −0.02 (0.141) | 40; 0.041 (0.131) | 39; −0.181 (0.119) | −0.005 (0.033); 0.022; 0.883 | 0.136 (0.214); 0.404; 0.525 | −0.02 (0.046); 0.19; 0.663 |
| Inosine | 40; −0.109 (0.159) | 39; 0.112 (0.159) | 40; 0.154 (0.12) | 39; 0.083 (0.155) | 40; 0.062 (0.148) | 39; 0.055 (0.16) | −0.011 (0.028); 0.155; 0.694 | −0.133 (0.198); 0.451; 0.502 | 0.028 (0.039); 0.526; 0.468 |
| Inosinic acid | 40; 0.008 (0.17) | 39; −0.008 (0.149) | 40; −0.085 (0.171) | 39; 0.136 (0.161) | 40; −0.113 (0.174) | 39; −0.159 (0.159) | −0.046 (0.022); 4.373; 0.037 | −0.128 (0.218); 0.344; 0.558 | 0.032 (0.04); 0.641; 0.423 |
| Isobutyryl-L-carnitine | 40; −0.09 (0.145) | 39; 0.092 (0.174) | 40; −0.285 (0.134) | 39; −0.131 (0.165) | 40; −0.555 (0.139) | 39; −0.192 (0.175) | −0.067 (0.022); 9.072; 0.003 | −0.102 (0.225); 0.206; 0.65 | −0.042 (0.031); 1.906; 0.167 |
| Isovalerylcarnitine | 40; 0.035 (0.134) | 39; −0.035 (0.183) | 40; −0.001 (0.128) | 39; −0.214 (0.176) | 40; −0.385 (0.145) | 39; −0.147 (0.154) | −0.025 (0.03); 0.698; 0.403 | 0.073 (0.219); 0.112; 0.738 | −0.059 (0.041); 2.097; 0.148 |
| Kynurenic acid | 40; 0.057 (0.137) | 39; −0.059 (0.181) | 40; −0.065 (0.133) | 39; −0.23 (0.167) | 40; 0.118 (0.155) | 39; −0.066 (0.175) | 0.013 (0.027); 0.236; 0.627 | 0.133 (0.225); 0.351; 0.554 | 0.011 (0.038); 0.079; 0.779 |
| L-Acetylcarnitine | 40; 0.049 (0.154) | 39; −0.05 (0.166) | 40; −0.027 (0.171) | 39; −0.111 (0.168) | 40; 0.044 (0.2) | 39; −0.009 (0.16) | 0.004 (0.044); 0.007; 0.931 | 0.129 (0.227); 0.322; 0.57 | −0.009 (0.058); 0.023; 0.88 |
| L-Alanine | 40; −0.119 (0.166) | 39; 0.122 (0.151) | 40; −0.152 (0.184) | 39; 0.02 (0.142) | 40; −0.485 (0.168) | 39; −0.373 (0.149) | −0.093 (0.028); 10.741; 0.001 | −0.262 (0.23); 1.298; 0.255 | 0.029 (0.039); 0.569; 0.451 |
| L-Arginine | 40; 0.023 (0.153) | 39; −0.024 (0.167) | 40; 0.054 (0.149) | 39; −0.008 (0.151) | 40; 0.225 (0.148) | 39; 0.097 (0.172) | 0.022 (0.019); 1.408; 0.235 | 0.025 (0.226); 0.012; 0.912 | 0.016 (0.03); 0.277; 0.599 |
| L-Asparagine | 40; −0.08 (0.166) | 39; 0.082 (0.152) | 40; −0.129 (0.181) | 39; 0.023 (0.155) | 40; 0.13 (0.167) | 39; 0.092 (0.161) | 0.013 (0.025); 0.261; 0.61 | −0.17 (0.226); 0.564; 0.453 | 0.046 (0.032); 2.072; 0.15 |
| L-Aspartic acid | 40; 0.107 (0.165) | 39; −0.109 (0.153) | 40; −0.375 (0.143) | 39; −0.205 (0.163) | 40; −0.091 (0.175) | 39; −0.333 (0.157) | −0.038 (0.031); 1.457; 0.227 | 0.065 (0.219); 0.087; 0.767 | 0.025 (0.051); 0.241; 0.624 |
| L-Carnitine | 40; −0.027 (0.16) | 39; 0.028 (0.16) | 40; −0.065 (0.163) | 39; 0.059 (0.154) | 40; −0.128 (0.17) | 39; 0.159 (0.154) | 0.026 (0.014); 3.701; 0.054 | −0.113 (0.227); 0.248; 0.618 | −0.049 (0.02); 5.801; 0.016 |
| L-Cystathionine | 40; -0.184 (0.13) | 39; 0.189 (0.181) | 40; −0.378 (0.122) | 39; 0.058 (0.187) | 40; −0.457 (0.117) | 39; 0.09 (0.175) | −0.027 (0.023); 1.368; 0.242 | −0.384 (0.22); 3.037; 0.081 | −0.039 (0.035); 1.229; 0.268 |
| L-Glutamic acid | 40; 0.159 (0.171) | 39; −0.163 (0.143) | 40; 0.062 (0.136) | 39; −0.033 (0.152) | 40; 0.053 (0.126) | 39; −0.198 (0.131) | 0.017 (0.022); 0.564; 0.453 | 0.292 (0.218); 1.788; 0.181 | −0.047 (0.036); 1.776; 0.183 |
| L-Glutamine | 40; −0.089 (0.15) | 39; 0.091 (0.169) | 40; −0.04 (0.148) | 39; 0.136 (0.17) | 40; 0.064 (0.136) | 39; 0.095 (0.153) | −0.083 (0.088); 0.896; 0.344 | −0.353 (0.473); 0.558; 0.455 | 0.088 (0.121); 0.53; 0.467 |
| L-Histidine | 40; 0.006 (0.161) | 39; −0.006 (0.159) | 40; 0.013 (0.144) | 39; −0.036 (0.16) | 40; 0.155 (0.164) | 39; 0.104 (0.176) | 0.026 (0.025); 1.094; 0.296 | −0.009 (0.221); 0.002; 0.968 | 0.004 (0.035); 0.015; 0.903 |
| L-Homoserine | 40; −0.017 (0.167) | 39; 0.017 (0.152) | 40; −0.243 (0.156) | 39; −0.11 (0.145) | 40; −0.319 (0.155) | 39; −0.604 (0.148) | −0.116 (0.028); 17.574; 0 | −0.081 (0.201); 0.161; 0.688 | 0.072 (0.047); 2.341; 0.126 |
| L-Isoleucine | 40; 0.043 (0.161) | 39; −0.044 (0.158) | 40; −0.162 (0.133) | 39; −0.154 (0.171) | 40; −0.13 (0.144) | 39; −0.122 (0.155) | −0.008 (0.014); 0.29; 0.59 | 0.048 (0.223); 0.047; 0.828 | −0.02 (0.027); 0.516; 0.473 |
| L-Kynurenine | 40; −0.082 (0.148) | 39; 0.084 (0.171) | 40; −0.128 (0.138) | 39; 0.101 (0.163) | 40; 0.159 (0.159) | 39; 0.252 (0.191) | 0.035 (0.032); 1.198; 0.274 | −0.255 (0.221); 1.33; 0.249 | 0.024 (0.043); 0.307; 0.58 |
| L-Leucine | 40; 0.051 (0.151) | 39; −0.052 (0.169) | 40; −0.102 (0.167) | 39; −0.24 (0.161) | 40; 0.05 (0.169) | 39; 0.049 (0.188) | 0.042 (0.016); 6.525; 0.011 | 0.117 (0.226); 0.266; 0.606 | −0.03 (0.028); 1.136; 0.286 |
| L-Lysine | 40; 0.184 (0.152) | 39; −0.188 (0.163) | 40; 0.266 (0.162) | 39; −0.151 (0.159) | 40; 0.236 (0.159) | 39; 0.061 (0.202) | 0.062 (0.029); 4.611; 0.032 | 0.349 (0.226); 2.375; 0.123 | −0.053 (0.042); 1.572; 0.21 |
| L-Methionine | 40; 0.015 (0.154) | 39; −0.016 (0.166) | 40; −0.182 (0.151) | 39; −0.086 (0.169) | 40; −0.103 (0.16) | 39; −0.224 (0.148) | −0.039 (0.022); 3.154; 0.076 | −0.037 (0.227); 0.027; 0.87 | 0.012 (0.035); 0.118; 0.731 |
| L-Octanoylcarnitine | 40; 0.049 (0.162) | 39; −0.05 (0.158) | 40; −0.032 (0.187) | 39; −0.292 (0.163) | 40; −0.236 (0.179) | 39; −0.237 (0.115) | −0.012 (0.033); 0.131; 0.717 | 0.095 (0.226); 0.176; 0.675 | −0.037 (0.043); 0.768; 0.381 |
| L-Ornithine | 40; 0.051 (0.161) | 39; −0.052 (0.158) | 40; −0.152 (0.167) | 39; −0.094 (0.168) | 40; −0.161 (0.169) | 39; −0.086 (0.155) | −0.005 (0.019); 0.059; 0.809 | 0.032 (0.23); 0.019; 0.889 | −0.019 (0.031); 0.373; 0.541 |
| L-Phenylalanine | 40; 0.061 (0.167) | 39; −0.062 (0.151) | 40; −0.129 (0.145) | 39; −0.225 (0.145) | 40; 0.011 (0.153) | 39; −0.201 (0.14) | −0.046 (0.014); 10.562; 0.001 | 0.088 (0.228); 0.15; 0.698 | 0.013 (0.03); 0.194; 0.66 |
| L-Proline | 40; 0.162 (0.171) | 39; −0.166 (0.143) | 40; 0.06 (0.169) | 39; −0.163 (0.132) | 40; −0.212 (0.186) | 39; −0.355 (0.153) | −0.03 (0.031); 0.936; 0.333 | 0.33 (0.228); 2.091; 0.148 | −0.05 (0.041); 1.504; 0.22 |
| L-Serine | 40; −0.006 (0.129) | 39; 0.006 (0.188) | 40; −0.056 (0.127) | 39; 0.168 (0.194) | 40; 0.093 (0.145) | 39; 0.233 (0.18) | 0.037 (0.026); 2.04; 0.153 | −0.136 (0.226); 0.363; 0.547 | −0.016 (0.033); 0.23; 0.632 |
| L-Threonine | 40; 0.004 (0.149) | 39; −0.004 (0.171) | 40; −0.098 (0.143) | 39; −0.047 (0.169) | 40; −0.241 (0.189) | 39; −0.443 (0.137) | −0.081 (0.026); 10.062; 0.002 | −0.022 (0.221); 0.01; 0.922 | 0.026 (0.042); 0.375; 0.54 |
| L-Tryptophan | 40; −0.009 (0.138) | 39; 0.009 (0.18) | 40; −0.272 (0.145) | 39; −0.262 (0.174) | 40; −0.179 (0.154) | 39; −0.298 (0.151) | −0.078 (0.029); 7.173; 0.007 | −0.083 (0.228); 0.134; 0.714 | 0.036 (0.038); 0.871; 0.351 |
| L-Tyrosine | 40; 0.035 (0.153) | 39; −0.036 (0.167) | 40; −0.225 (0.16) | 39; −0.226 (0.162) | 40; −0.323 (0.155) | 39; −0.216 (0.187) | −0.032 (0.018); 3.203; 0.073 | 0.035 (0.23); 0.023; 0.879 | −0.045 (0.028); 2.544; 0.111 |
| L-Valine | 40; 0.148 (0.138) | 39; −0.152 (0.177) | 40; −0.008 (0.145) | 39; −0.282 (0.164) | 40; 0.025 (0.168) | 39; −0.096 (0.169) | 0.022 (0.025); 0.745; 0.388 | 0.312 (0.225); 1.926; 0.165 | −0.04 (0.037); 1.185; 0.276 |
| Myo-inositol | 40; −0.009 (0.156) | 39; 0.01 (0.164) | 40; −0.171 (0.142) | 39; 0.024 (0.196) | 40; 0.181 (0.16) | 39; 0.09 (0.163) | 0.024 (0.027); 0.833; 0.361 | −0.133 (0.227); 0.345; 0.557 | 0.031 (0.043); 0.517; 0.472 |
| N(tele)-methylhistamine | 40; −0.108 (0.158) | 39; 0.111 (0.161) | 40; −0.047 (0.148) | 39; 0.175 (0.15) | 40; 0.016 (0.152) | 39; 0.094 (0.162) | −0.004 (0.013); 0.072; 0.788 | −0.349 (0.214); 2.66; 0.103 | 0.032 (0.023); 1.863; 0.172 |
| NAD | 40; −0.08 (0.168) | 39; 0.082 (0.15) | 40; −0.056 (0.135) | 39; 0.135 (0.177) | 40; −0.08 (0.133) | 39; 0.022 (0.156) | −0.019 (0.025); 0.593; 0.441 | −0.222 (0.205); 1.178; 0.278 | 0.015 (0.042); 0.134; 0.714 |
| Niacinamide | 40; 0.23 (0.143) | 39; −0.236 (0.168) | 40; 0.929 (0.189) | 39; 0.394 (0.147) | 40; 0.377 (0.162) | 39; −0.08 (0.175) | 0.045 (0.037); 1.425; 0.233 | 0.463 (0.226); 4.194; 0.041 | −0.003 (0.052); 0.003; 0.958 |
| Normetanephrine | 40; 0.053 (0.176) | 39; −0.054 (0.142) | 40; 0.287 (0.145) | 39; 0.376 (0.177) | 40; 0.22 (0.144) | 39; 0.301 (0.148) | 0.065 (0.023); 7.89; 0.005 | 0.026 (0.221); 0.013; 0.908 | −0.032 (0.039); 0.672; 0.412 |
| O-Phosphoethanolamine | 40; 0.002 (0.136) | 39; −0.002 (0.182) | 40; −0.053 (0.138) | 39; 0.079 (0.122) | 40; −0.049 (0.143) | 39; 0.075 (0.15) | 0.018 (0.036); 0.242; 0.623 | −0.072 (0.198); 0.133; 0.716 | −0.029 (0.041); 0.508; 0.476 |
| Orotic acid | 40; 0.087 (0.155) | 39; −0.089 (0.164) | 40; −0.139 (0.187) | 39; 0.256 (0.219) | 40; 0.026 (0.158) | 39; 0.045 (0.161) | −0.007 (0.029); 0.058; 0.809 | −0.117 (0.228); 0.264; 0.607 | 0.019 (0.039); 0.237; 0.626 |
| Pantothenic acid | 40; 0.058 (0.153) | 39; −0.059 (0.166) | 40; −0.074 (0.151) | 39; −0.054 (0.191) | 40; 0.011 (0.157) | 39; −0.123 (0.193) | −0.018 (0.023); 0.652; 0.419 | 0.029 (0.227); 0.016; 0.899 | 0.023 (0.033); 0.499; 0.48 |
| Propionylcarnitine | 40; 0.051 (0.138) | 39; −0.052 (0.18) | 40; −0.168 (0.141) | 39; −0.235 (0.174) | 40; −0.404 (0.142) | 39; −0.103 (0.18) | −0.027 (0.017); 2.461; 0.117 | 0.09 (0.231); 0.153; 0.696 | −0.085 (0.026); 10.381; 0.001 |
| Sorbitol | 40; −0.02 (0.184) | 39; 0.02 (0.13) | 40; −0.199 (0.187) | 39; −0.012 (0.133) | 40; 0.028 (0.188) | 39; −0.174 (0.142) | −0.032 (0.017); 3.476; 0.062 | −0.095 (0.228); 0.173; 0.677 | 0.036 (0.037); 0.962; 0.327 |
| Spermidine | 40; −0.156 (0.173) | 39; 0.16 (0.14) | 40; −0.033 (0.171) | 39; 0.47 (0.181) | 40; 0.378 (0.191) | 39; 0.562 (0.162) | 0.069 (0.024); 8.464; 0.004 | −0.441 (0.229); 3.722; 0.054 | 0.045 (0.035); 1.636; 0.201 |
| Succinic acid | 40; −0.057 (0.157) | 39; 0.058 (0.163) | 40; −0.282 (0.158) | 39; −0.253 (0.152) | 40; −0.27 (0.141) | 39; −0.121 (0.171) | −0.015 (0.022); 0.47; 0.493 | −0.038 (0.218); 0.03; 0.863 | −0.014 (0.032); 0.198; 0.656 |
| Sucrose | 40; 0.054 (0.156) | 39; −0.056 (0.164) | 40; −0.049 (0.16) | 39; 0.088 (0.134) | 40; 0.068 (0.147) | 39; −0.039 (0.144) | 0.003 (0.02); 0.022; 0.882 | 0.029 (0.206); 0.02; 0.889 | 0.004 (0.03); 0.021; 0.885 |
| Symmetric dimethylarginine | 40; −0.224 (0.161) | 39; 0.23 (0.15) | 40; −0.169 (0.154) | 39; 0.113 (0.148) | 40; 0.201 (0.154) | 39; 0.378 (0.134) | 0.037 (0.026); 2.134; 0.144 | −0.481 (0.22); 4.752; 0.029 | 0.06 (0.04); 2.222; 0.136 |
| Taurine | 40; 0.102 (0.158) | 39; −0.104 (0.16) | 40; −0.285 (0.138) | 39; −0.114 (0.155) | 40; −0.057 (0.161) | 39; −0.079 (0.159) | 0.014 (0.04); 0.129; 0.72 | 0.126 (0.218); 0.334; 0.563 | −0.039 (0.052); 0.575; 0.448 |
| Taurochenodesoxycholic acid | 40; 0.057 (0.171) | 39; −0.059 (0.147) | 40; −0.222 (0.158) | 39; −0.401 (0.129) | 40; −0.487 (0.131) | 39; −0.332 (0.145) | −0.078 (0.03); 6.61; 0.01 | 0.187 (0.223); 0.705; 0.401 | −0.059 (0.042); 1.97; 0.16 |
| Taurocholic acid | 40; 0.02 (0.138) | 39; −0.021 (0.18) | 40; −0.064 (0.138) | 39; −0.152 (0.17) | 40; 0.011 (0.16) | 39; −0.047 (0.186) | −0.014 (0.035); 0.155; 0.694 | 0.064 (0.224); 0.083; 0.773 | 0.005 (0.047); 0.01; 0.919 |
| trans-4-Hydroxy-L-proline | 40; 0.012 (0.165) | 39; −0.012 (0.154) | 40; 0.01 (0.163) | 39; 0.007 (0.152) | 40; −0.301 (0.159) | 39; −0.166 (0.165) | 0.008 (0.033); 0.062; 0.803 | 0.006 (0.233); 0.001; 0.979 | −0.032 (0.043); 0.555; 0.456 |
| Trimethylamine N-oxide | 40; −0.046 (0.144) | 39; 0.047 (0.175) | 40; −0.058 (0.139) | 39; 0.099 (0.181) | 40; −0.131 (0.147) | 39; 0.043 (0.178) | 0.018 (0.03); 0.347; 0.556 | −0.019 (0.223); 0.007; 0.931 | −0.037 (0.038); 0.934; 0.334 |
| Uracil | 40; 0.038 (0.177) | 39; −0.039 (0.141) | 40; −0.165 (0.176) | 39; −0.158 (0.154) | 40; −0.011 (0.134) | 39; −0.235 (0.155) | −0.031 (0.031); 0.986; 0.321 | 0.058 (0.202); 0.083; 0.773 | 0.03 (0.044); 0.482; 0.488 |
| Xanthine | 40; 0.107 (0.155) | 39; −0.11 (0.163) | 40; −0.092 (0.145) | 39; −0.092 (0.169) | 40; 0.278 (0.158) | 39; −0.296 (0.135) | −0.039 (0.03); 1.726; 0.189 | 0.065 (0.212); 0.095; 0.758 | 0.103 (0.042); 5.941; 0.015 |
| Xanthosine | 40; 0.138 (0.153) | 39; −0.141 (0.164) | 40; 0.086 (0.166) | 39; 0.023 (0.144) | 40; 0.064 (0.177) | 39; −0.155 (0.149) | −0.003 (0.024); 0.018; 0.893 | 0.227 (0.209); 1.183; 0.277 | −0.001 (0.044); 0; 0.989 |
*values represent: “N; Mean (SE)”; **values represent: “Estimate (SE); Wald statistic; P-value”; ^“Group” coefficient specified in the model as variation in the tDCS group respect to the Sham.