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. 2020 May 7;11:804. doi: 10.3389/fmicb.2020.00804

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Copyright © 2020 Chen, Johnson, Yu, Nelson and Walker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of differential gene expression between E. anophelis Ag1 cultures held in low- and high-iron culture conditions. (A) Heat maps of 100 genes with significant regulation by iron availability. Left, high-iron condition; right, low-iron condition. (B) Magnitude amplitude plots generated by a modifying function within the edgeR package. Red dots indicate statistically significant genes (adjusted P < 0.05) and black dots are non-statistically significant differentially regulated genes. Blue lines indicate two-fold changes either up-regulated or down-regulated.