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. 2020 May 7;11:804. doi: 10.3389/fmicb.2020.00804

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Copyright © 2020 Chen, Johnson, Yu, Nelson and Walker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KEGG and STRING analysis of differentially regulated genes in E. anophelis Ag1. (A) KEGG pathway enrichment analysis of up-regulated DEGs. Most of up-regulated DEGs were enriched to Energy Metabolism. (B) KEGG pathway enrichment analysis of down-regulated DEGs. Down-regulated genes were predominantly enriched in the Genetic Information Processing. (C) STRING analysis of up-regulated DEGs. Up-regulated DEGs were clustered to oxidative phosphorylation (circled). (D) STRING analysis of down-regulated DEGs. Down-regulated DEGs were clustered to ribosome and the biosynthesis of phenylalanine, tyrosine and tryptophan (circled).