Table 1.

List of the contents and sizes of all simulation systems.

Simulated System	PDB	C36 Replicates	Drude Replicates	Solution	Box Size (Å)
c-kit2 WT	N/A†	3 × 1 μs	3 × 1 μs	~150 mM KCl	61
T21	2KQH	3 × 1 μs	3 × 1 μs	~150 mM KCl	61
A10/T21	2KQG	3 × 1 μs	3 × 1 μs	~150 mM KCl	53
T12/T21	2KYP	3 × 1 μs	3 × 1 μs	~150 mM KCl	54
T12/T21	2KYP	3 × 1 μs	3 × 1 μs	~150 mM NaCl	54
T12/T21	2KYP	3 × 1 μs	3 × 1 μs	~150 mM LiCl	54
c-kit*	6GH0	3 × 1 μs	2 × 1 μs 1 × 1.5 μs	~150 mM KCl	54
Linked c-kit2/c-kit*	N/A†	N/A	3 × 500 ns	~150 mM KCl	113

^†These systems were constructed as described in the Methods.