Table 1.

Transcription factors in cell competition. Summary of known transcription factors that play a role in several cell competition contexts as well the activities they produce. Dros. (Drosophila), Mam. (mammals).

Transcription Factors	Competition context	Model	Activity	Key Studies
p53	Irradiated bone marrow	Mam.	Increased p53 in losers	Bondar and Medzhitov [24]
	Myc overexpression in epithelial cells	Dros.	Increased p53 in winners	de la Cova et al. [28]
	Bmpr1a-/- and 4n mESCs	Mam.	Increased p53 in losers	Bowling [26]
	ScribkD MDCK cells	Mam.	Increased p53 in losers	Wagstaff [27]
	Mdm2+/-, Mdm4+/- embryos	Mam.	Increased p53 in losers	Zhang et al. [25]
Myc	Myc overexpression in epithelial cells	Dros.	Increased Myc activity induces super-competition and increases p53 levels	de la Cova [4] Moreno and Basler[3] de la Cova et al. [28]
	Bmpr1a-/- or Tetraploid mESCs	Mam.	Decreased MYC in losers	Sancho et al. [15]
	Scrib- epithelial cells	Dros.	Increased Myc activity rescues loser cell elimination	Chen et al. [9]
	Lgl- epithelial cells	Dros.	Decreased Myc levels	Froldi et al. [14]
	Myc overexpression in mouse cardiomyocytes and epiblast cells	Mam.	High MYC levels produces super-competition	Clavería et al. [16] Villa del Campo et al. [17,18], Díaz-Díaz et al. [87]
	MYC inhibition in cancer cell lines	Mam.	Decreased MYC induces loser status	Di Giacomo et al. [21] Patel et al. [20]
	Myc overexpression in S2 cells	Dros.	Increased Myc induces winner status	Senoo-Matsuda and Johnston [19]
NF-κB	Minute+/-epithelial cells	Dros.	Increased activity in losers	Meyer et al. [54] Germani et al. [55]
	Myc overexpression in in epithelial cells	Dros.	Increased activity in losers	Meyer et al. [54] Alpar et al. [88] Germani et al. [55]
	Scrib- epithelial cells	Dros.	Increased activity in winners	Katsukawa et al. [56]
STAT	Minute+/-; Mahjong+/- epithelial cells	Dros.	STAT promotes winner proliferation	Kolahgar et al. [34] Kucinski et al. [35]
	Stat92E85C9 epithelial cells and sustained STAT in epithelial cells	Dros.	Decreased STAT induces loser status and STAT activity induces super-competition	Rodrigues et al. [33]
YAP/Yki TEAD/ Scalloped	Scrib- epithelial cells	Dros.	Suppressed Yki activity in losers	Chen et al. [9] Yamamoto et al. [39]
	lgl- epithelial cells	Dros.	Increased Yki activity in winners	Menéndez et al. [38]
	Minute+/- epithelial cells	Dros.	Increased Yki activity rescues loser elimination	Tyler et al. [40]
	APC-/- epithelial cells	Dros.	Increased Yki activity rescues loser elimination	Suijkerbuijk et al. [42]
	Hippo pathway manipulation in epithelial cells	Dros.	Increased Yki activity induces super-competition	Ziosi et al. [43]
	Hippo pathway manipulation in embryonic fibroblasts	Mam.	Increased Yki activity induces super-competition, decreased Yki activity induces loser status	Mamada et al. [44]
	Hippo pathway manipulation in the epiblast	Mam.	Decreased TEAD activity induces loser status	Hashimoto and Sasaki [45]