FIGURE 8.

Decision curve analysis and comparison of the nomograms with the AJCC stages. Decision curve analysis of the nomograms for predicting (A) 1‐, 2‐, and 3‐y CSS in the training cohort; (B) 1‐, 2‐, and 3‐y OS in the training cohort; (C) 1‐, 2‐, and 3‐y CSS in the validation cohort; (D) 1‐, 2‐, and 3‐y OS in the validation cohort; (E) 1‐, 2‐, and 3‐y CSS in the test cohort; and (F) 1‐, 2‐, and 3‐y OS in the test cohort; comparison of the nomograms with the 8th version of the AJCC stages for predicting (G) 3‐y CSS in the training cohort; (H) 3‐y OS in the training cohort. Black horizontal lines represented the assumption that events occurred in no patient within a particular timespan. Red lines represented the assumption that events occurred in all patients within the same time span. Blue lines indicated the net benefit of model prediction. The net benefit per patient of each predictive model within a particular time span was a function of the cohort size with threshold probability, and was computed by addition of the benefit (true positive) and subtraction of the harm (false positive). AJCC, American Joint Committee on Cancer; CSS, cancer‐specific survival; OS, overall survival