Table 2. Recurrence and treatment.
| Variables | Values |
|---|---|
| Follow-up duration (month) | |
| Median (range) | 19.9 (7–177) |
| Interval, initial CCRT-first recurrence (month) | |
| Median (range) | 7.1 (1–92.7) |
| First recurrent tumor size (cm) | |
| Median (range) | 5.5 (1.4–13.8) |
| First recurrence site | |
| In-field | 25 (69.4) |
| Out-field | 4 (11.1) |
| In- and out-field | 7 (19.4) |
| Treatment at first recurrence | |
| Operation | 4 (11.1) |
| Radiotherapy | 9 (25) |
| Operation+radiotherapy | 2 (5.6) |
| Radiotherapy+chemotherapy | 12 (33.3) |
| Operation+chemotherapy | 1 (2.8) |
| Operation+radiotherapy+chemotherapy | 8 (22.2) |
| Surgical resection | |
| Yes | 17 (47.2) |
| No | 19 (52.8) |
| Surgical resection extent | |
| GTR | 4 (23.5) |
| NTR | 7 (41.2) |
| STR | 6 (35.3) |
| MGMT methylation at surgical resection | |
| (+) | 0 (0) |
| (-) | 1 (5.9) |
| NA | 16 (94.1) |
| IDH-1 at surgical resection | |
| (+) | 0 (0) |
| (-) | 12 (70.6) |
| NA | 5 (29.4) |
| Ki-67 at surgical resection (%) | |
| Median (range) | 20 (10–60) |
| Second recurrence | |
| Yes | 22 (61.1) |
| No | 9 (25) |
| NA | 5 (13.9) |
| Treatment at second recurrence | |
| Yes | 19 (86.4) |
| No | 3 (13.6) |
| Surgical resection at second recurrence | |
| Yes | 6 (27.3) |
| No | 16 (72.7) |
| Re-irradiation at second recurrence | |
| Yes | 14 (63.6) |
| No | 8 (36.4) |
| Last follow-up status | |
| No evidence of disease | 3 (8.3) |
| Alive with disease | 19 (52.8) |
| Death from disease | 14 (38.9) |
Data are presented as number (%) unless otherwise noticed. CCRT, concurrent chemoradiotherapy; GTR, gross total resection; NTR, near-total resection; STR, subtotal resection; MGMT, O6-methylguanine-DNA methyltransferase; IDH, isocitrate dehydrogenase; NA, not assessable