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. Author manuscript; available in PMC: 2020 May 14.
Published in final edited form as: Neurochem Int. 2019 Sep 20;131:104552. doi: 10.1016/j.neuint.2019.104552

Fig. 1.

Fig. 1.

Effect of (±)-citalopram on (±)-epibatidine-induced Ca2+ influx in HEK293-hα3β4 (A), HEK293-hα4β2 (B), and GH3-hα7 (C) cells. Increased concentrations of (±)-epibatidine (■) activated each hα3β4 (A), hα4β2 (B), and hα7 (C) AChR. Subsequently, cells were pre-treated (5 min) with several concentrations of (±)-citalopram (□), followed by addition of 0.1 μM (+)-epibatidine. Response was normalized to the maximal (±)-epibatidine response which was set as 100%. The plots are representative of 4-5 determinations, where the error bars are the S.D. The calculated IC50 and nH values are summarized in Table 1.