Table 2.
Demographics of 405 patients included in the study.
| Variables | N = 405 | Univariate analysisP value |
Multivariate analysis |
|
|---|---|---|---|---|
| Hazard ratio (95% CI) | P | |||
| Gender (male/female) | 356/49 | 0.067 | ||
| Age (years) | 52 (22–78) | 0.769 | ||
| Child-Pugh grade (A/B) | 389/16 | 0.005 | 2.548 (1.374–4.726) | 0.003 |
| ALT (U/L) | 33.5 (6–344.5) | 0.002 | ||
| AST (U/L) | 30.4 (12.8–355.7) | 0.000 | ||
| γ-GT (U/L) | 52.7 (8.6–1588.60) | 0.000 | ||
| Total bilirubin (Umol/L) | 15.1 (4.4–248.9) | 0.060 | ||
| INR | 1.11 (0.83–1.58) | 0.927 | ||
| Albumin (g/L) | 40.9 (23.5–52.6) | 0.056 | ||
| PLT (109/L) | 160 (40–466) | 0.160 | ||
| AFP (IU/mL) | 51.89 (0.61–24,200) | 0.001 | ||
| Tumor number (1/2–3/>3) | 345/33/27 | 0.000 | ||
| Maximal tumor diameter (cm) | 4.8 (0.8–26) | 0.000 | 1.482 (1.263–1.738) | 0.000 |
| Cirrhosis (yes/no) | 323/82 | 0.914 | ||
| Capsulation (yes/no) | 101/301 | 0.429 | ||
| MVTT (yes/no) | 21/384 | 0.012 | ||
| TNM stage (I/II/III) | 340/30/35 | 0.000 | 1.655 (1.348–2.032) | 0.000 |
| AAR | 0.92 (0.35–6.09) | 0.106 | ||
| AARP (0/1) | 138/267 | 0.942 | ||
| AARPRI | 0.85 (0.22–7.75) | 0.540 | ||
| API | 6 (0–10) | 0.498 | ||
| APRI | 0.4511 (0.11–3.23) | 0.000 | 1.550 (1.101–2.183) | 0.012 |
| CDS | 6 (1–9) | 0.161 | ||
| FIB-4 Index | 1.80 (0.49–12.98) | 0.014 | ||
| Fibro-α Score | 1.83 (1.02–233.25) | 0.000 | 1.420 (1.030–1.960) | 0.033 |
| Fibrosis Index | 2.26 (0.25–4.42) | 0.263 | ||
| Firbro Q | 3.4 (0.73–40.55) | 0.247 | ||
| GUCI | 0.50 (0.12–4.04) | 0.001 | ||
| King Score | 11.61 (2.65–99.13) | 0.002 | ||
| P2/MS | 63.50 (4.13–506.9) | 0.193 | ||
| PLASA Score | 0.52 (–1.74–5.26) | 0.006 | ||
| Pohl Score (0/1) | 318/87 | 0.351 | ||
ALT: alanine aminotransferase; AST: aspartate aminotransferase; γ-GT: γ-glutamyl transpeptidase; INR: international normalized ratio; PLT: platelet count; AFP: alpha-fetoprotein; MVTT: micro-vascular tumor thrombus; AAR: aspartate aminotransferase to alanine aminotransferase ratio; AARP: AAR-platelet score; AARPRI: AAR-to-platelet ratio index; API: age-platelet index; APRI: AST to platelet ratio index; CDS: cirrhosis discriminant score; FIB-4 Index: fibrosis index based on the four factors; Fibro Q: fibro-quotient; GUCI: Goteburg University Cirrhosis Index; PLASA: platelet-AST-age; CI: confidence interval.