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Synthesis of FEtLos ([19F]fluoroethyl-losartan, cold derivative) by O-alkylation of commercially available losartan potassium (1) using two strategies, (A) direct nucleophilic substitution of 1 with 2-fluoroethyl tosylate (2) or (B) a three steps procedure through protection of the N-tetrazol moiety of 1, followed by O-alkylation and deprotection.
