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. 2020 Apr 18;25(8):1872. doi: 10.3390/molecules25081872

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 3 — Radiosynthesis of [¹⁸F]FEtLos ([¹⁸F]fluoroethyl-losartan) by direct nucleophilic substitution of commercially available losartan potassium (1) with 2-[¹⁸F]fluoroethyl tosylate (2*), and formation of the isomer N-[¹⁸F]fluoroethyl-losartan (3*) as side-product.