Table 2.
Summary of FISH technique value in solid tumors.
| Type of Tumor | Diagnostic Value | Prognostic Value | Predictive Value | Available FISH Probe |
|---|---|---|---|---|
| Lung cancer ALK, ROS1 |
no | yes | yes crizotinib |
▪ Vysis ALK Break Apart FISH Probe Kit (Abbott Molecular) [7,40] ▪ Vysis 6q22 ROS1 Break Apart FISH Probe (Abbott Molecular) [41] ▪ ROS1 Break Apart FISH Probe (Empire Genomics) |
| Glioma co-deletion 1p19q |
yes | yes | No | ▪ Vysis LSI 1p36 SpectrumOrange/1q25 SpectrumGreen Probes and Vysis LSI 19q13 SpectrumOrange/19p13 SpectrumGreen Probes (Abbott Molecular) [13] |
| Breast cancer HER2 |
no | yes | yes trastuzumab, lapatinib |
▪ PathVysion HER-2 DNA Probe Kit (Abbott Molecular) [37] |
| Ovarian cancer CCNE1 |
no | yes | yes platinum-based agents |
▪ CCNE1/CEN19p FISH Probe (Abnova) [23] |
| Ewing sarcoma EWSR1 |
yes | yes | No | ▪ Vysis EWSR1 Break Apart FISH Probe Kit (Abbott Molecular) [14] |
| Synovial sarcoma SS18 |
yes | yes | No | ▪ Vysis SS18 Break Apart FISH Probe Kit (Abbot Molecular) [14] |
| Dermatofibrosarcoma protuberans COL1A1-PDGFB |
no | yes | yes TKI (imatinib) |
▪ SPEC COL1A1-PDGFB Dual Color Dual Fusion (ZytoLight) [42] |