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Metal complexation: Sb(III) (violet) forms a stable complex with catalytic residues. Similarly, Au(I) (orange) displays a planar-trigonal coordination (Ilari et al., 2012) with Cys52, Cys57, and a chloride ion (green). The thiosugar moiety (cyan) participates in the inhibition mechanism interacting with His466′, Glu466′, and Glu467′. Residues are shown as sticks, light grey for inhibitor-free TR (PDB: 2jk6), dark grey for Au-bound TR (PDB: 2yau), and black for Sb-bound TR (PDB: 2w0h).
