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. 2020 May 4;14:1705–1716. doi: 10.2147/DDDT.S235969

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© 2020 Gao et al.

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Suppression of autophagy and enhancement of lysosomal function by CGA in APP/PS1 mice.

Notes: (A) Representative Western blot imagines of LC3B-II/LC3B-I (16/18 KDa), p62/SQSTM (75 KDa), and cathepsin D (24 KDa) in the brains of APP/PS1 mice (left panel). β-actin (43 KDa) was used as a control for protein loading. The right panel shows the relative optical density values of LC3B-II/LC3B-I, p62/SQSTM, and cathepsin D between the experimental groups. (B) Representative Western blot imagines of mTOR (298 KDa), p-mTOR (298 KDa), p70s6k (59KDA) and p-p70s6k (59KDA) in the brains of APP/PS1 mice, and representative Western blot imagines of TFEB (65 KDa) indicating nuclear protein and total protein (left panel); lamin A/C (74/63 KDa) or β-actin (43 KDa) was used as a control for protein loading. The right panel shows the relative optical density values of mTOR and p-mTOR between the experimental groups and the relative optical density values of TFEB between the experimental groups. Data are expressed as the mean ± s.e.m for eight samples per treatment group. **P<0.01 compared with the WT group; ^##P<0.01 compared with the APP/PS1 group.