Table 2. Risk Factors for Cutaneous SCC Among 9793 Lung Transplants.
| Characteristic | AHR (95% CI)a |
|---|---|
| Sex | |
| Female | 1 [Reference] |
| Male | 2.01 (1.73-2.32) |
| Age at transplant per categoryb | 1.54 (1.44-1.65) |
| Indication for transplant | |
| Chronic obstructive pulmonary disease | 1 [Reference] |
| Idiopathic pulmonary fibrosis | 1.44 (1.23-1.69) |
| Otherc | 1.28 (1.05-1.55) |
| Smoking history | |
| No | 1 [Reference] |
| Yes | 1.28 (1.10-1.49) |
| Daily mean annual ambient UVR, mW/m2 | |
| <26.00 | 1 [Reference] |
| 26.00-31.99 | 0.94 (0.79-1.13) |
| 32.00-46.99 | 0.94 (0.79-1.12) |
| ≥47.00 | 1.11 (0.94-1.32) |
| Transplant No. | |
| First | 1 [Reference] |
| Second or greater | 2.49 (1.92-3.23) |
| Duration of voriconazole used | |
| No use | 1 [Reference] |
| 1-3 mo | 1.09 (0.90-1.31) |
| 4-7 mo | 1.42 (1.16-1.73) |
| 8-15 mo | 2.04 (1.67-2.50) |
| >15 mo | 3.05 (2.37-3.91) |
| Ever itraconazole use | |
| No | 1 [Reference] |
| Yes | 1.20 (1.00-1.45) |
| Unknown | 0.94 (0.73-1.21) |
| Ever posaconazole use | |
| No | 1 [Reference] |
| Yes | 1.08 (0.83-1.39) |
| Unknown | 1.02 (0.75-1.40) |
| Ever other antifungal usee | |
| No | 1 [Reference] |
| Yes | 1.10 (0.89-1.36) |
| Unknown | 1.32 (0.98-1.76) |
Abbreviations: AHR, adjusted hazard ratio; SCC, squamous cell carcinoma; UVR, UV radiation.
Cox proportional hazards regression models are adjusted for all variables in the table. The baseline hazard was stratified by calendar year of transplantation (2007-2008, 2009-2010, 2011-2012, 2013-2014, and 2015-2016).
Categorized as an ordinal variable corresponding to the following ranges: less than 30, 30 to 39, 40 to 49, 50 to 59, 60 to 69, and older than 69 years.
Includes cystic fibrosis, other obstructive lung diseases, inflammatory and fibrotic lung, airway diseases, pulmonary hypertension and pulmonary vascular diseases, and other or unspecified conditions.
Assessed in 30-day increments; duration of use categories correspond to approximately less than the 33rd, 33rd to 66th, 66th to 90th, and greater than 90th percentiles.
Includes fluconazole, amphotericin B, caspofungin acetate, micafungin sodium, anidulafungin, and isavuconazonium sulfate.