Table 3. Risk Factors for Cutaneous BCC Among 9793 Lung Transplants.
| Characteristic | AHR (95% CI)a |
|---|---|
| Sex | |
| Female | 1 [Reference] |
| Male | 1.62 (1.28-2.06) |
| Age at transplant per categoryb | 1.37 (1.23-1.52) |
| Smoking history | |
| No | 1 [Reference] |
| Yes | 1.33 (1.03-1.72) |
| Daily mean annual ambient UVR, mW/m2 | |
| <26.00 | 1 [Reference] |
| 26.00-31.99 | 0.79 (0.59-1.06) |
| 32.00-46.99 | 0.68 (0.50-0.92) |
| ≥47.00 | 1.02 (0.77-1.36) |
| Ever voriconazole use | |
| No | 1 [Reference] |
| Yes | 0.88 (0.64-1.21) |
| Unknown | 0.92 (0.59-1.44) |
| Ever itraconazole use | |
| No | 1 [Reference] |
| Yes | 1.74 (1.27-2.37) |
| Unknown | 1.18 (0.77-1.81) |
| Ever posaconazole use | |
| No | 1 [Reference] |
| Yes | 1.55 (1.00-2.41) |
| Unknown | 1.52 (0.87-2.66) |
| Ever other antifungal usec | |
| No | 1 [Reference] |
| Yes | 0.90 (0.60-1.35) |
| Unknown | 0.75 (0.45-1.24) |
Abbreviations: AHR, adjusted hazard ratio; BCC, basal cell carcinoma; UVR, UV radiation.
a
Cox proportional hazards regression models are adjusted for all variables in the table. The baseline hazard was stratified by calendar year of transplantation (2007-2008, 2009-2010, 2011-2012, 2013-2014, and 2015-2016).
b
Categorized as an ordinal variable corresponding to the following age ranges: less than 30, 30 to 39, 40 to 49, 50 to 59, 60 to 69, and greater than 69 years.
c
Includes fluconazole, amphotericin B, caspofungin acetate, micafungin sodium, anidulafungin, and isavuconazonium sulfate.