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. 2020 Apr 18;25(8):1877. doi: 10.3390/molecules25081877

Figure 2.

Figure 2

Biodistribution (A–C) and silencing activity in vivo (D) of cholesterol-modified siRNAs. (A) Biodistribution of Ch-siRNA and Ch-TsiRNA-2 in organs of mice 24 h after i.v. injection (2.5 nmole—1.7 and 5 µg/g, respectively). (B) Accumulation of Ch-siRNA and Ch-TsiRNA-2 in xenograft KB-8-5 tumors 24 h after i.v. injection (1.1 nmole—0.5 and 1.5 µg/g, respectively). (C) Concentration of Ch-siRNA and Ch-TsiRNA-2 in the blood of mice after i.v. injection of 2.5 nmole—1.7 and 5 µg/g, respectively. (D) Silencing activity of Ch-siRNA, Ch-TsiRNA-1 and Ch-TsiRNA-2 in xenograft KB-8-5 tumors in 6 days after i.v. injection (8.5 µg/g).