Figure 2.

Inhibitory effect of PROTAC compounds on the viability of two different cancer cell lines, MCF7 (a) and A549 (b). PROTAC compounds were treated at 1 or 10 μM of concentration for 3 days in a complete RPMI-1640 medium. At various concentrations of CPR3 (c) or CPR4 (d), the IC₅₀ value was calculated through the growth curve in both cell lines. Cell viability was determined by the changes in absorbance at 570 nm. * P ≤ 0.05 and ** P ≤ 0.01, as determined by Student’s t-test.