Table 2.

Summary of NPs effects in in vitro model of fibrosarcoma.

Nanoparticles Type	Fibrosarcoma Cell Line	Effect	Additional Comment	Reference
Gold NPs 127 nm	HT-1080	Anti-metastatic effect	NPs did not affect cells viability   AuNPs interfered actin-polymerisation pathway   AuNPs inhabited cells migration	[34]
Silver NPs 6 nm	WEHI164	Cytotoxicity	IC50 of AgNPs was 2.6 μg/mL	[35]
Iron (II, III) oxide NPs 10 nm	HT-1080	Cytotoxicity	NPs had magnetic properties   NPs may be used as drug delivery platform	[36]
Iron (II, III) oxide NPs 10 nm, 100 nm	HT-1080	Cytotoxicity Genotoxicity	NPs were coated with: -OH, -NH2, -TEOS, -AMPTS or TEOS/AMPTS functional groups   Cytotoxicity and genotoxicity were function group – dependent   AMPTS coated NPs were the most cytotoxic   Positively charged NPs were more genotoxic than negatively charged	[37]
Cerium oxide NPs 25 nm	HT-1080	Non-cytotoxic		[38]
Cerium oxide NPs 30 nm	WEHI164	Cytotoxicity	Cancer cells were more susceptible to NPs than non-transformed ones   NPs triggered oxidative stress   NPs caused apoptosis	[39]
Chromium oxide NPs	L929	Cytotoxicity	NPs triggered oxidative stress   NPs caused apoptosis	[40]