Table 1.

Preliminary nepafenac aggregate formulations. All contain a mixture of 15% (w/v) γ-CD and 8% (w/v) HPβ-CD in aqueous solution [41].

Formulations
F2 = 1.0% (w/v) CMC
F3 = 2.0% (w/v) PVA + 1.0% (w/v) CMC+ 0.1% (w/v) Tyloxapol
F5 = 1.0% (w/v) PVP + 1.0% (w/v) CMC + 0.1% (w/v) HPMC
F9 = 2.0% (w/v) PVA + 1.0% (w/v) CMC + 0.1% (w/v) MC

CD, cyclodextrin; HPβ, hydroxypropyl-β; CMC, carboxymethylcellulose; HPMC, hydroxypropylmethylcellulose; MC, methyl cellulose; PVA, hydrolyzed poly(vinyl alcohol); PVP, polyvinylpyrrolidone.