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In vitro drug release rate ang goodness of fit of ACTH ointments using Higuchi’s model (n = 6); *—p < 0.05.
| Formulation | Average Release Rate (mg/cm2/min1/2) ± SD | R2 |
|---|---|---|
| F-5 (15 mg/g) | 0.41 ± 0.02 | 0.98 |
| F-6 (20 mg/g) | 0.48 ± 0.05 | 0.98 |
| F-7 (25 mg/g) | 0.52 ± 0.03 * | 0.92 |
