TABLE 1.
Baseline demographics
| DIAN | MC (N = 121) | NC (healthy reference (N = 54) | P | |
|---|---|---|---|---|
| Age | 38.66 (9.98) | 38.87 (10.48) | 0.8998 | |
| Sex (m/f) | 49/72 | 19/35 | 0.5056 | |
| Education | 14.27 (3.02) | 15.50 (2.23) | 0.0081 | |
| MMSE | 27.74(7.88) | 30.00 (0.00) | 0.0365 | |
| Logical-memory | 11.44(5.9) | 15.78 (3.45) | <0.0001 | |
| EYO | −7.10 (11.23) | −9.35 (10.94) | 0.2185 | |
| ADNI | MCI-Aβ+ (N = 216) | MCI-Aβ− (N = 175) | CN (healthy reference) (N = 49) | P |
| Age | 72.74 (6.69) | 70.16(7.76) | 65.76 (2.69) | <0.0001 |
| Sex (m/f) | 117/99 | 94/81 | 23/26 | 0.6345 |
| Education | 16.00 (2.79) | 16.47 (2.47) | 17.14 (2.27) | 0.0139 |
| MMSE | 27.68(1.83) | 28.54 (1.44) | 29.51(0.51) | <0.0001 |
| ADAS13 | 17.18(6.96) | 12.21 (5.48) | 6.24 (3.83) | <0.0001 |
| ADNI-MEM | 0.11 (0.63) | 0.62 (0.63) | 1.46 (0.61) | <0.0001 |
Values are displayed as mean (standard deviation). P-values for group comparisons are derived from two-sample t tests for DIAN and ANOVAs for ADNI for continuous measures and Chi-squared tests for categorical measures. Abbreviations: EYO, estimated years to symptom onset; MC, mutation carrier; MMSE, Mini-Mental State Exam; NC, non-carrier