Skip to main content
. 2020 May 13;9:F1000 Faculty Rev-354. [Version 1] doi: 10.12688/f1000research.22877.1

Figure 1. The PVR–TIGIT axis.

Figure 1.

PVR and Nectin-2 are expressed on APCs or tumor cells. TIGIT, CD96, and DNAM-1 are expressed on cytotoxic effector cells (CD8 + T cells and NK cells). PVR affinity for TIGIT is higher than its affinity for CD96 or DNAM-1. Thus, the signaling of the PVR–TIGIT synapse induces immunosuppression rather than effector cell activation and/or cytotoxicity. Signaling through PVR induces anti-inflammatory profiles in dendritic cells and macrophages. CD96 signaling induces immunosuppression in murine models, which was not demonstrated in human models. Similar to PVR, Nectin-2 binds PVR, CD96, or DNAM-1 but with a lower affinity than PVR. APC, antigen-presenting cell; DNAM-1, DNAX accessory molecule-1; NK, natural killer; PVR, poliovirus receptor; TIGIT, T Cell Immunoreceptor with Ig and ITIM domains.