Table 1.
Baseline characteristics and outcome of study patients
| All patients n = 3250 | Patients never colonized with ESBL-GNB n = 3060 | Patients colonized with ESBL-GNB at admission n = 131 | Patients with acquired ESBL-GNB colonization n = 59 | Patients with non-ESBL-GNB acquired infection n = 192 | Patients with ESBL-GNB acquired infection n = 15 | |
|---|---|---|---|---|---|---|
| Age, years [IQR] | 62.1 [51.0–71.0] | 62.0 [50.0–70.9] | 65.8 [56.0–72.0] | 66.0 [56.3–75.0] | 64.8 [55.0–71.5] | 70. 7 [64.5–75.5] |
| Simplified Acute Physiology Score II [IQR] | 40 [28–56] | 39 [28–55.0] | 46 [3 3–58] | 48 [34–62] | 51 [38–64] | 61 [46–67] |
| Reason for admission, no. (%) | ||||||
| Surgical | 443 (13.6) | 412 (13.5) | 17 (13.9) | 13 (22.0) | 33 (17.2) | 2 (13.3) |
| Medical | 2445 (75.2) | 2346 (76.6) | 105 (80.2) | 41 (69.5) | 132 (68.8) | 13 (86.6) |
| Not precise | 362 (11.1) | 302 (9.9) | 9 (6.9) | 5 (8.5) | 27 (14.1) | – |
| Male, no. (%) | 2074 (63.8) | 1936 (63.3) | 92 (70.2) | 45 (76.3) | 144 (75.0) | 12 (80.0) |
| ESBL-GNB colonization at admission, no. (%) | 131 (4.0) | 0 | 131 (100) | – | 3 (1.6) | 4 (26.6) |
| ESBL-GNB acquired colonization, no. (%) | 59 (1.8) | – | – | 59 (100) | 10 (5.2) | 4 (26.7) § |
| Days after admission, days [IQR]* | 7 [5-14] | – | – | 7 [5-14] | 14 [11-25] | 10 [8-14] |
| ESBL-GNB acquired infection, no. (%) | 15 (0.5) | 7 (0.2) | 4 (3.1) | 4 (6.8) § | – | 15 (100) |
| Intubation duration > 48 h, no. (%) | 1507 (46.4) | 1395 (45.6) | 61 (46.6) | 51 (86.4) | 163 (84.9) | 13 (86.6) |
| Length of stay in ICU, days [IQR] | 4 [3–9] | 4 [2–8] | 5 [3–9] | 16 [9–33] | 20 [9–35] | 25 [12–41] |
| Death in ICU, no. (%) | 645 (19.8) | 596 (19.5) | 37 (28.2) | 12 (20.3) | 63 (32.8) | 5 (33.3) |
ICU intensive care unit ESBL-GNB extended-spectrum beta-lactamase-producing Gram-negative bacilli
*In patients with acquired colonization only