Table 5.

Initial antibiotic treatment of central nervous system infections after organ transplantation [42]

Infection type	Treatment
Acute meningitis/meningoencephalitis Subacute/chronic meningitis	Empiric treatment depends on clinical situation and most likely diagnosis Ceftriaxone + vancomycin + ampicillin* ± acyclovir or ganciclovir Consider adding lipid amphotericin if clinical suspicion for cryptococcal infection** Consider ganciclovir if there is CSF lymphocytic pleocytosis*** Consider doxycycline in endemic area for rocky mountain spotted fever Depends on clinical situation and most likely diagnosis
Brain abscess	Meropenem ± vancomycin Consider adding voriconazole or lipid formulation amphotericin

CSF, cerebrospinal fluid; TMP/SMX, trimethoprim/sulfamethoxazole

*For Listeria, especially if a patient is not on TMP/ SMX

**While waiting for cryptococcal test results

***Especially if encephalopathic