Table 1.
Author (Year) | Country | BW GA | Dosage (ml) Interval (h) Duration (days) | Control | Sample size (E/C) | Primary outcomes | Secondary outcomes | |||
---|---|---|---|---|---|---|---|---|---|---|
NEC | Late-onset Sepsis | Death | Time to reach full enteral feeding (days) (E/C) | Duration of hospital stay (days) (E/C) | ||||||
Abd-Elgawad et al. [22] | Egypt |
<1500 g <32 weeks |
0.2 ml/ 2~4 h/ NG | No intervention | 100/100 | 3/8 | 8/13 | 11/16 |
11.10 ± 2.1 days 15.57 ± 1.5 days |
46.0 ± 5 days 61.6 ± 9 days |
Ferreira et al. [17] | Brazil |
<1500 g <34 weeks |
0.2 ml/ 2 h/ 2 days | Placebo | 47/66 | 1/1 | 21/34 | 2/8 |
20 (18–26) days 24 (18–25) days; |
66.0 (48–84) days 64.5 (49–79) days |
Sharma et al. [33] | India |
<1250 g ≤30 weeks |
0.2 ml/ 2 h/ 3 days | No intervention | 59/58 | 0/3 | 8/10 | 3/4 |
10.1 ± 5.7 days 10.7 ± 4.3 days |
34.2 ± 5.7 days 41.5 ± 6.7 days |
Zhang et al. [23] | China | ≤1250 g | 0.2 ml/ 4 h/ 7 days | Placebo | 27/28 | 1/5 | 3/6 | NG |
24.71 ± 11.23 days 32.72 ± 20.11 days |
NG |
Glass et al. [18] | America | <1500 g | 0.2 ml/ 3 h/ 5 days | Placebo | 17/13 | 3/2 | 5/3 | NG |
24.2 ± 7.9 days 24.9 ± 9.4 days |
NG |
Romano-Keeler et al. [35] | America | <32 weeks | 0.2 ml/ 6 h/ 5 days | No intervention | 48/51 | 2/1 | 1/3 | NG |
11 (8–15) days 11 (9–19) days |
NG |
Sohn et al. (2015) | America | <1500 g | 0.2 ml/ 2 h/ 2 days | No intervention | 6/6 | 2/1 | 0/2 | 0/1 | NG | NG |
Lee et al. [34] | Korea | <28 weeks | 0.2 ml/ 3 h/ 3 days | Placebo | 24/24 | 4/6 | 11/14 | 3/6 |
20 (13–27) days 17(14.3–25.8) days |
89(69.3–109.8) days 81.5(56.5–99) days |
Rodriguez et al. [37] | America |
<1000 g <28 weeks |
0.2 ml/ 2 h/ 2 days | Placebo | 9/6 | 0/0 | 3/0 | 2/0 |
14.29 ± 5.74 days 24.17 ± 8.66 days |
101.43 ± 44.26 days 85.33 ± 32.96 days |
NG not given, BW birth weight, GA gestation age, E experimental group, C control group