Table 2.
Plasma biomarker levels in the study sample (63 males and 147 females) within the EPIC Granada–Gipuzkoa study.
| Biomarkes | All | Men | Women | |||||
|---|---|---|---|---|---|---|---|---|
| N = 210 | N = 63 | N = 147 | ||||||
| Median | IQR (25–75) | N | Median | IQR (25–75) | Median | IQR (25–75) | p-Value 1 | |
| Ascorbic acid (µmol/L) | 27.8 | [20.9;46.3] | 210 | 28.2 | [23.9;54.0] | 27.8 | [20.4;42.7] | 0.201 |
| Dehydroascorbic acid (µmol/L) | 0.00 | [0.00;3.76] | 210 | 0.00 | [0.00;6.85] | 0.00 | [0.00;0.00] | 0.007 |
| Total vitamin C (µmol/L) | 29.3 | [21.4;52.5] | 210 | 31.6 | [24.3;64.3] | 28.9 | [20.4;44.5] | 0.113 |
| Retinol (µmol/L) | 2.22 | [1.85;2.73] | 210 | 2.31 | [1.94;2.81] | 2.16 | [1.79;2.66] | 0.066 |
| Tocopherol (µmol/L) | 28.4 | [21.6;37.3] | 210 | 27.3 | [20.7;37.0] | 29.4 | [21.7;37.5] | 0.410 |
| Carotenes (µmol/L) | 3.47 | [2.34;6.73] | 210 | 2.79 | [1.80;4.27] | 3.92 | [2.62;7.65] | <0.001 |
| Q9 (µmol/L) | 0.05 | [0.03;0.08] | 210 | 0.05 | [0.03;0.09] | 0.05 | [0.03;0.07] | 0.727 |
| Q10 (µmol/L) | 1.16 | [0.96;1.50] | 210 | 1.17 | [1.00;1.59] | 1.15 | [0.95;1.50] | 0.662 |
| Uric acid (mg/dl) | 3.73 | [3.05;4.48] | 210 | 4.71 | [3.96;5.41] | 3.45 | [2.92;4.03] | <0.001 |
| FRAP (µmol TE/L) | 457 | [403;519] | 210 | 528 | [471;560] | 428 | [393;476] | <0.001 |
| FRAP (µmol Fe2+/L) | 881 | [808;982] | 210 | 996 | [910;1079] | 853 | [785;924] | <0.001 |
| FRAP without uric ccid (µmol TE/L) | 314 | [267;355] | 210 | 345 | [312;387] | 296 | [257;341] | <0.001 |
| FRAP without uric acid (µmol Fe2+/L) | 634 | [574;699] | 210 | 692 | [630;754] | 616 | [556;678] | <0.001 |
| TRAP (µmol TE/L) | 976 | [884;1073] | 210 | 1034 | [907;1116] | 949 | [867;1047] | 0.001 |
| TEAC-ABTS (µmol TE/L) | 3041 | [2599;3677] | 210 | 3115 | [2508;3823] | 3008 | [2647;3384] | 0.642 |
| Total polyphenols (mg GAE/L) | 1207 | [1128;1276] | 210 | 1206 | [1126;1270] | 1207 | [1132;1277] | 0.850 |
| ORAC without proteins (µmol TE/L) | 1160 | [946;1399] | 210 | 1308 | [1098;1555] | 1124 | [908;1358] | <0.001 |
| ORAC (µmol TE/L) | 14,706 | [12,739;17,005] | 210 | 15,138 | [13,185;17,622] | 14,547 | [12,617;16,648] | 0.173 |
| CRP (mg/L) | 1.26 | [0.76;2.38] | 207 | 1.18 | [0.76;2.15] | 1.32 | [0.76;2.50] | 0.299 |
| Adiponectin (µg/mL) | 0.10 | [0.07;0.15] | 207 | 0,08 | [0.06;0.11] | 0.10 | [0.07;0.17] | 0.014 |
| PAI-I (ng/mL) | 20.0 | [14.6;27.0] | 210 | 22.9 | [17.9;29.8] | 19.4 | [14.3;25.2] | 0.008 |
| Resistin (ng/mL) | 14.2 | [11.5;18.2] | 210 | 13.3 | [10.5;16.1] | 14.4 | [12.0;18.8] | 0.024 |
| TNF-α (pg/mL) | 0.75 | [0.58;1.00] | 162 | 0.77 | [0.62;1.06] | 0.74 | [0.51;0.98] | 0.323 |
| IL-8 (pg/mL) | 1.08 | [0.68;1.70] | 146 | 1.09 | [0.68;1.68] | 1.06 | [0.69;1.71] | 0.850 |
| IL-6 (pg/mL) | 0.69 | [0.69;0.69] | 210 | 0.69 | [0.69;0.69] | 0.69 | [0.69;0.69] | 0.776 |
IQR = P25–P75 1 Wilcoxon’s test for continuous variables. CRP: C-reactive protein; PAI-I: Plasminogen activator inhibitor-1; TNF-α: Tumor necrosis factor.