Table 3.
Association between P-NEAC as TRAP and the nutrient/inflammation biomarkers in the EPIC Granada–Gipuzkoa cohort sub-sample (n = 210).
| Biomarkers | Model 1 | Model 2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| β Coefficient | CI 95% | p-Value | R2 | β Coefficient | CI 95% | p-Value | R2 | |||
| Ascorbic acid (µmol/L) | −0.018 | −0.038 | 0.002 | 8.47 × 10−2 | 0.199 | −0.020 | −0.040 | 0.001 | 6.16 × 10−2 | 0.219 |
| Dehydroascorbic acid (µmol/L) | 0.000 | −0.001 | 0.001 | 9.33 × 10−1 | 0.187 | 0.000 | −0.001 | 0.001 | 9.71 × 10−1 | 0.205 |
| Total vitamin C (µmol/L) | −0.011 | −0.029 | 0.007 | 2.22 × 10−1 | 0.193 | −0.013 | −0.031 | 0.006 | 1.70 × 10−1 | 0.212 |
| Retinol (µmol/L) | −0.010 | −0.051 | 0.031 | 6.30 × 10−1 | 0.188 | −0.009 | −0.051 | 0.033 | 6.68 × 10−1 | 0.206 |
| α-Tocopherol (µmol/L) | −0.013 | −0.041 | 0.015 | 3.68 × 10−1 | 0.190 | −0.015 | −0.043 | 0.014 | 3.17 × 10−1 | 0.209 |
| Carotenes (µmol/L) | −0.002 | −0.016 | 0.012 | 8.23 × 10−1 | 0.187 | −0.003 | −0.017 | 0.012 | 6.90 × 10−1 | 0.206 |
| Q9 (µmol/L) | −0.010 | −0.024 | 0.004 | 1.80 × 10−1 | 0.194 | −0.011 | −0.026 | 0.003 | 1.27 × 10−1 | 0.214 |
| Q10 (µmol/L) | −0.001 | −0.027 | 0.025 | 9.55 × 10−1 | 0.187 | −0.002 | −0.029 | 0.025 | 9.1 × 10−1 | 0.205 |
| Uric acid (mg/dl) | 0.042 | 0.000 | 0.084 | 5.33 × 10−2 | 0.202 | 0.046 | 0.000 | 0.091 | 5.03 × 10−2 | 0.220 |
| FRAP (µmol TE/L) | 0.164 | 0.091 | 0.238 | 1.86 × 10−5 | 0.257 | 0.166 | 0.090 | 0.243 | 3.25 × 10−5 | 0.271 |
| FRAP (µmol Fe2+/L) | 0.110 | 0.030 | 0.190 | 7.88 × 10−3 | 0.215 | 0.102 | 0.019 | 0.186 | 1.73 × 10−2 | 0.227 |
| FRAP without uric ccid (µmol TE/L) | 0.143 | 0.079 | 0.207 | 1.84 × 10−5 | 0.257 | 0.139 | 0.074 | 0.205 | 4.54 × 10−5 | 0.269 |
| FRAP without uric acid (µmol Fe2+/L) | 0.083 | 0.010 | 0.155 | 2.59 × 10−2 | 0.206 | 0.072 | −0.002 | 0.147 | 5.85 × 10−2 | 0.219 |
| TEAC-ABTS (µmol TE/L) | 0.046 | 0.003 | 0.088 | 3.80 × 10−2 | 0.204 | 0.051 | 0.007 | 0.094 | 2.49 × 10−2 | 0.225 |
| Total polyphenols (mg GAE/L) | 0.144 | 0.018 | 0.269 | 2.58 × 10−2 | 0.206 | 0.146 | 0.012 | 0.280 | 3.45 × 10−2 | 0.223 |
| ORAC without proteins (µmol TE/L) | 0.033 | −0.008 | 0.075 | 1.18 × 10−1 | 0.197 | 0.039 | −0.004 | 0.081 | 7.78 × 10−2 | 0.217 |
| ORAC (µmol TE/L) | 0.077 | 0.021 | 0.133 | 7.45 × 10−3 | 0.215 | 0.079 | 0.022 | 0.135 | 7.29 × 10−3 | 0.233 |
| CRP (mg/L) | −0.004 | −0.016 | 0.009 | 5.78 × 10−1 | 0.187 | −0.004 | −0.018 | 0.010 | 5.43 × 10−1 | 0.205 |
| Adiponectin (µg/mL) | 0.006 | −0.008 | 0.020 | 3.95 × 10−1 | 0.195 | 0.007 | −0.008 | 0.021 | 3.69 × 10−1 | 0.216 |
| PAI-I (ng/mL) | 0.007 | −0.017 | 0.031 | 5.61 × 10−1 | 0.188 | 0.008 | −0.016 | 0.033 | 5.14 × 10−1 | 0.207 |
| Resistin (ng/mL) | −0.025 | −0.056 | 0.006 | 1.19 × 10−1 | 0.197 | −0.025 | −0.057 | 0.007 | 1.24 × 10−1 | 0.214 |
| TNF-α (pg/mL) | −0.008 | −0.035 | 0.019 | 5.55 × 10−1 | 0.202 | −0.008 | −0.036 | 0.019 | 5.55 × 10−1 | 0.219 |
| IL-8 (pg/mL) | −0.006 | −0.023 | 0.010 | 4.50 × 10−1 | 0.254 | −0.006 | −0.022 | 0.011 | 5.26 × 10−1 | 0.278 |
| IL-6 (pg/mL) | −0.001 | −0.017 | 0.015 | 8.93 × 10−1 | 0.187 | −0.002 | −0.018 | 0.015 | 8.19 × 10−1 | 0.205 |
Plasma biomarkers were log2 transformed. Model 1: Multiple linear regression adjusted for age (continuous, years), sex (male, females) and center (Granada, Gipuzkoa). Model 2: Multiple linear regression adjusted age (continuous, years), sex (male, females) and center (Granada, Gipuzkoa), BMI (continuous, kg/m2), physical activity (inactive, moderately inactive and active, active) and smoking status (never, former, current smoker). Statistically significant associations are shown in bold.