Table 4.
Association between P-NEAC as FRAP and the nutrient/inflammation biomarkers in the EPIC Granada–Gipuzkoa cohort sub-sample (n = 210).
| Biomarkers | Model 1 | Model 2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| β Coefficient | CI 95% | p-Value | R2 | β Coeff | CI 95% | p-Value | R2 | |||
| Ascorbic Acid (µmol/L) | 0.027 | 0.004 | 0.051 | 2.38 × 10−2 | 0.247 | 0.027 | 0.003 | 0.050 | 2.81 × 10−2 | 0.292 |
| Dehydroascorbic acid (µmol/L) | 0.001 | 0.000 | 0.001 | 1.73 × 10−1 | 0.235 | 0.001 | 0.000 | 0.001 | 1.64 × 10−1 | 0.281 |
| Total vitamin C (µmol/L) | 0.017 | −0.004 | 0.038 | 1.07 × 10−1 | 0.238 | 0.017 | −0.004 | 0.038 | 1.21 × 10−1 | 0.283 |
| Retinol (µmol/L) | 0.081 | 0.035 | 0.127 | 7.18 × 10−4 | 0.270 | 0.080 | 0.033 | 0.127 | 9.92 × 10−4 | 0.313 |
| α-Tocopherol (µmol/L) | 0.050 | 0.018 | 0.082 | 2.27 × 10−3 | 0.263 | 0.050 | 0.018 | 0.082 | 2.77 × 10−3 | 0.306 |
| Carotenes (µmol/L) | 0.017 | 0.001 | 0.033 | 3.78 × 10−2 | 0.244 | 0.017 | 0.001 | 0.034 | 3.76 × 10−2 | 0.290 |
| Q9 (µmol/L) | 0.013 | −0.003 | 0.030 | 1.12 × 10−1 | 0.238 | 0.011 | −0.005 | 0.028 | 1.90 × 10−1 | 0.280 |
| Q10 (µmol/L) | 0.062 | 0.033 | 0.091 | 4.13 × 10−5 | 0.289 | 0.062 | 0.032 | 0.092 | 6.43 × 10−5 | 0.331 |
| Uric acid (mg/dl) | 0.245 | 0.209 | 0.282 | 2.02 × 10−29 | 0.585 | 0.252 | 0.213 | 0.291 | 1.06 × 10−27 | 0.603 |
| TRAP (µmol TE/L) | 0.149 | 0.040 | 0.257 | 7.88 × 10−3 | 0.254 | 0.133 | 0.024 | 0.242 | 1.73 × 10−2 | 0.295 |
| TEAC-ABTS (µmol TE/L) | −0.015 | −0.066 | 0.035 | 5.49 × 10−1 | 0.230 | −0.018 | −0.068 | 0.033 | 4.90 × 10−1 | 0.276 |
| Total polyphenols (mg GAE/L) | 0.262 | 0.119 | 0.406 | 4.20 × 10−4 | 0.274 | 0.246 | 0.095 | 0.397 | 1.65 × 10−3 | 0.310 |
| ORAC without proteins (µmol TE/L) | 0.033 | −0.016 | 0.082 | 1.85 × 10−1 | 0.235 | 0.031 | −0.019 | 0.079 | 2.24 × 10−1 | 0.280 |
| ORAC (µmol TE/L) | −0.037 | −0.103 | 0.029 | 2.72 × 10−1 | 0.233 | −0.043 | −0.109 | 0.023 | 2.02 × 10−1 | 0.280 |
| CRP (mg/L) | 0.002 | −0.013 | 0.016 | 8.37 × 10−1 | 0.229 | −0.004 | −0.019 | 0.012 | 6.44 × 10−1 | 0.277 |
| Adiponectin (µg/mL) | −0.005 | −0.021 | 0.011 | 5.29 × 10−1 | 0.231 | −0.002 | −0.018 | 0.014 | 8.11 × 10−1 | 0.276 |
| PAI-I (ng/mL) | 0.019 | −0.009 | 0.046 | 1.88 × 10−1 | 0.235 | 0.010 | −0.018 | 0.039 | 4.68 × 10−1 | 0.276 |
| Resistin (ng/mL) | 0.011 | −0.026 | 0.047 | 5.73 × 10−1 | 0.229 | 0.007 | −0.030 | 0.043 | 7.24 × 10−1 | 0.275 |
| TNF-α (pg/mL) | 0.022 | −0.009 | 0.053 | 1.68 × 10−1 | 0.207 | 0.016 | −0.015 | 0.047 | 3.14 × 10−1 | 0.252 |
| IL-8 (pg/mL) | −0.003 | −0.023 | 0.016 | 7.40 × 10−1 | 0.201 | −0.008 | −0.028 | 0.012 | 4.40 × 10−1 | 0.232 |
| IL-6 (pg/mL) | −0.016 | −0.035 | 0.002 | 8.73 × 10−2 | 0.239 | −0.016 | −0.035 | 0.002 | 8.97 × 10−2 | 0.285 |
Plasma biomarkers were log2 transformed. Model 1: Multiple linear regression adjusted for age (continuous, years), sex (male, females) and center (Granada, Gipuzkoa). Model 2: Multiple linear regression adjusted age (continuous, years), sex (male, females) and center (Granada, Gipuzkoa), BMI (continuous, kg/m2), physical activity (inactive, moderately inactive and active, active) and smoking status (never, former, current smoker). Statistically significant associations are shown in bold.