Table 2.

Detailed analysis of DE and DAS gene-involved pathways, with their possible impact on retinal dystrophies etiopathogenesis. DE and DAS genes were dysregulated during the whole analysis and showed several fluctuations during observed time points, suggesting that changes in gene-level expression and alternative splicing occurred throughout the whole period, either transiently (occurring after 3 h and returning to initial level after 6 h), occurring later (only after 6 h from treatment) or enduring throughout the whole period.

De Gene-Involved Pathways	Expression Changes	Das Gene-Involved Pathways
RNA methyltransferase	3 h and 6 h = DOWN-REGULATED	Endosomal sorting complex required for transport (ESCRT) and RAB geranylgeranylation
TRAF6 mediated NF-kB activation and activation of IKK by MEKK1		Phagopore assembly site membrane; C-terminal protein lipidation; protein localization to microtubule cytoskeleton; regulation of TNFR1 signaling; TNF signaling
Condensed chromosome outer kinetochore and kinesin complex		Methylation; activation of chaperone genes; nucleotide-sugar biosynthetic process
Transport of nucleoside and free purine and pyrimidine; histone pre-mRNA DCP binding; formation of AT-AC complex; respiratory electron transport	3 h and 6 h = UP-REGULATED	Negative regulation of FGFR1 signaling
		Regulation of telomerase RNA localization to Cajal body; maturation of LSU-rRNA; miRNAs involved in DNA damage response
		Mithocondrial intermembrane space and TP53 regulates transcription of cell death genes
		Polysomal ribosome
Mevalonate pathway and cholesterol biosynthesis	3 h = UP-REGULATED 6 h = DOWN-REGULATED	Cholesterol biosynthesis
CBL binds and ubiquinates Sprouty and MAP kinase phosphatase activity	3 h = DOWN-REGULATED 6 h = UP-REGULATED	/
PTK2/SRC-1 phosphorylates BCAR1