Table 2.

Pneumonitis in patients treated with PD-1/PD-L1 inhibitors.

	No. (%)
	Total (n = 276)	PD-1 inhibitors (n = 255)	PD-L1 inhibitors (n = 21)	Nivolumab (n = 109)	Pembrolizumab (n = 146)	Atezolizumab (n = 15)	Durvalumab (n = 6)
Pneumonitis	42 (15.22)	37 (14.51)	5 (23.81)	13 (11.93)	24 (16.44)	2 (13.33)	3 (50%)
Grade
1	30 (71.43)	26 (70.27)	4 (80)	9 (69.23)	17 (70.83)	1 (50)	3 (100)
2	5 (11.90)	5 (13.51)	0 (0)	3 (23.08)	2 (8.33)	0 (0)	0 (0)
3	5 (11.90)	4 (10.81)	1 (20)	0 (0)	4 (16.67)	1 (50)	0 (0)
4	2 (4.76)	2 (5.41)	0 (0)	1 (7.69)	1 (4.17)	0 (0)	0 (0)
Radiologic subtypes
COP	7 (16.67)	7 (18.92)	0 (0)	4 (30.77)	3 (12.5)	0 (0)	0 (0)
Ground glass opacities	6 (14.29)	4 (10.81)	2 (40)	1 (7.69)	3 (12.5)	0 (0)	2 (66.67)
Interstitial	13 (30.95)	12 (32.43)	1 (20)	1 (7.69)	11 (45.83)	0 (0)	1 (33.33)
Hypersensitivity	16 (38.10)	14 (37.84)	2 (40)	7 (53.85)	7 (29.17)	2 (100)	0 (0)
Systemic steroid therapy	12 (28.57)	11 (29.73)	1(20)	4 (30.77)	7 (29.17)	1 (50)	0 (0)
Days to onset, median (range), days	134 (20–687)	134 (20–687)	134 (20–687)	148 (21–565)	107.5 (20–687)	85 (82–88)	335 (46–336)

COP, Cryptogenic organizing pneumonia-like; PD-1, programmed cell death protein 1; PD-L1, programmed cell death ligand 1.