Table 2.
Subgroup analysis of OS.
| Analysis | N | Random-effect model |
Fixed-effect model |
Heterogeneity |
|||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | I2 (%) | Ph | ||
| Subgroup 1: Asian | 5 | 0.630 (0.337–1.178) | 0.148 | 0.936 (0.788–1.112) | 0.453 | 87.1 | 0.000 |
| Non-Asian | 6 | 0.666 (0.431–0.846) | 0.000 | 0.666 (0.534–0.831) | 0.000 | 0 | 0.478 |
| Subgroup 2: sample case < 100 | 5 | 0.455 (0.279–0.743) | 0.002 | 0.455 (0.279–0.743) | 0.002 | 0 | 0.774 |
| Sample case ⩾ 100 | 6 | 0.681 (0.454–1.022) | 0.064 | 0.865 (0.751–0.997) | 0.045 | 84.9 | 0.000 |
| Subgroup 3: Univariate analysis | 6 | 0.590 (0.429–0.810) | 0.001 | 0.629 (0.519–0.762) | 0.000 | 53.2 | 0.058 |
| Multivariate analysis | 5 | 0.608 (0.317–1.165) | 0.134 | 1.075 (0.888,1.302) | 0.457 | 74.0 | 0.004 |
| Subgroup 4: HGSC | 2 | 0.586 (0.291–1.178) | 0.133 | 0.683 (0.497–0.938) | 0.019 | 46.2 | 0.356 |
| OSCC | 2 | 0.479 (0.220–1.042) | 0.063 | 0.486 (0.241–0.980) | 0.044 | 17.3 | 0.271 |
| LC | 2 | 1.009 (0.502–2.028) | 0.980 | 1.223 (0.996–1.501) | 0.055 | 52.4 | 0.147 |
| Others | 5 | 0.542 (0.361,0.813) | 0.003 | 0.582 (0.461–0.734) | 0.000 | 58.0 | 0.023 |
CI, confidence interval; HGSC, high-grade serous ovarian cancer; HR, hazard ratio; LC, lung cancer; N, number of studies; OSCC, oral squamous cell carcinoma; Ph, p-value of Q test for heterogeneity.