Table 4.
Allele and genotype frequencies of polymorphisms in MTHFR between CAS group and control group
| Allele/Genotype | CAS-group | Control group | OR (CI 95%) | P-value | P for HWE | |||
|---|---|---|---|---|---|---|---|---|
| (n = 266) | (n = 464) | |||||||
| n | % | n | % | |||||
| ALL | C | 281 | 52.8 | 669 | 72.1 | 1 | 0.74 | |
| T | 251 | 47.2 | 259 | 27.9 | 2.31(1.85,2.88) | P < 0.001* | ||
| C/C | 58 | 21.8 | 249 | 53.7 | 1 | |||
| C/T | 165 | 62 | 171 | 36.9 | 4.14 (2.90,5.92) | P < 0.001* | ||
| T/T | 43 | 16.2 | 44 | 9.5 | 4.20(2.52,6.97) | P < 0.001* | ||
| Women | C | 82 | 52.6 | 231 | 84.9 | 1 | ||
| T | 74 | 47.4 | 41 | 15.1 | 5.08(3.22,8.03) | P < 0.001* | ||
| CC | 16 | 20.5 | 103 | 75.7 | 1 | |||
| CT | 50 | 64.1 | 25 | 18.4 | 12.88(6.31,26.26) | P < 0.001* | ||
| TT | 12 | 15.4 | 8 | 5.9 | 9.66(3.42,27.27) | P < 0.001* | ||
| Men | C | 199 | 52.9 | 438 | 66.8 | 1 | ||
| T | 177 | 47.1 | 218 | 33.2 | 1.79(1.38,2.32) | P < 0.001* | ||
| CC | 42 | 22.3 | 146 | 44.5 | 1 | |||
| CT | 115 | 61.2 | 146 | 44.5 | 2.74(1.80,4.17) | P < 0.001* | ||
| TT | 31 | 16.5 | 36 | 11 | 2.99(1.67,5.40) | P < 0.001* | ||
MTHFR Methylenetetrahydrofolate reductase, OR Odds ratio, CI Confidence interval, HWE Hardy-Weinberg equilibrium
*P<0.05 was considered to be statistically significant