Table 3.

Multivariate Cox analyses of treatment methods for OS (n = 21,030)

TNM Stage	Treatments	Multivariate HR (95% CI)	P value
T1-3N0M0			0.001
	Only surgery	Reference
	Surgery + chemotherapy	0.896(0.827–0.970)	0.007
	Neoadjuvant radiotherapy	1.171(1.019–1.347)	0.027
	Adjuvant radiotherapy	0.950(0.874–1.032)	0.223
T1-3N + M0			< 0.001
	Only surgery	Reference
	Surgery + chemotherapy	0.686(0.649–0.726)	< 0.001
	Neoadjuvant radiotherapy	0.751(0.635–0.887)	0.001
	Adjuvant radiotherapy	0.613(0.579–0.649)	< 0.001
T4N0M0			< 0.001
	Only surgery	Reference
	Surgery + chemotherapy	0.588(0.424–0.814)	0.001
	Neoadjuvant radiotherapy	0.482(0.347–0.670)	< 0.001
	Adjuvant radiotherapy	0.858(0.621–1.185)	0.353
T4N + M0			< 0.001
	Only surgery	Reference
	Surgery + chemotherapy	0.530(0.411–0.683)	< 0.001
	Neoadjuvant radiotherapy	0.338(0.215–0.532)	< 0.001
	Adjuvant radiotherapy	0.430(0.334–0.554)	< 0.001

OS Overall Survival, CI Confidence intervals, HR Hazard ratios