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. 2020 May 14;22:114. doi: 10.1186/s13075-020-02205-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Impact of the pre-treatments on mediators of inflammation and bone erosion. a Effects of pre-immunization with RgpA domains on mRNA expression levels of inflammatory markers in joint tissue of CIA rats. Real-time PCR was used to quantify expression of MMP9, CXCL1, TNF-alpha, IL-1b, and IL-17 in the ankle synovial tissues of rats. Expression levels were quantified by densitometric analysis of bands and normalized to those of GAPDH mRNA. Data are recorded as mean ± standard deviation from six animals per group. Results are presented as mean ± SEM. *p < 0.05; **p < 0.01; and ***p < 0.001. b Effects of pre-immunization with RgpA domains on serum levels of inflammatory markers in CIA rats. Levels of MMP9, CXCL1, TNF-alpha, IL-1b, and IL-17 were assessed in the sera of the different groups. Results are presented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001